Antifungal effect and action mechanism of antimicrobial peptide polybia-CP
文献类型: 外文期刊
第一作者: Wang, Kairong
作者: Wang, Kairong;Jia, Fengjing;Dang, Wen;Zhao, Yanyan;Zhu, Ranran;Sun, Mengyang;Qiu, Shuai;An, Xiaoping;Ma, Zelin;Zhu, Yuanyuan;Yan, Jiexi;Yan, Wenjin;Wang, Rui;Kong, Ziqing
作者机构:
关键词: antimicrobial peptide;polybia-CP;candidiasis;antifungal;ROS production
期刊名称:JOURNAL OF PEPTIDE SCIENCE ( 影响因子:1.905; 五年影响因子:2.244 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: The incidence of life-threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides are a class of potential lead chemical for the development of novel antifungal agents. Antimicrobial peptide polybia-CP was purified from the venom of the social wasp Polybia paulista. In this study, we synthesized polybia-CP and determined its antifungal effects against a series of Candidian species. Our results showed that polybia-CP has potent antifungal activity and fungicidal activity against the tested fungal cells with a proposed membrane-active action mode. In addition, polybia-CP could induce the increase of cellular reactive oxygen species production, which would attribute to its antifungal activity. In conclusion, the present study suggests that polybia-CP has potential as an antifungal agent or may offer a new strategy for antifungal therapeutic option. Copyright (c) 2015 European Peptide Society and John Wiley & Sons, Ltd.
分类号: Q516
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