Antifungal effect and action mechanism of antimicrobial peptide polybia-CP

文献类型: 外文期刊

第一作者: Wang, Kairong

作者: Wang, Kairong;Jia, Fengjing;Dang, Wen;Zhao, Yanyan;Zhu, Ranran;Sun, Mengyang;Qiu, Shuai;An, Xiaoping;Ma, Zelin;Zhu, Yuanyuan;Yan, Jiexi;Yan, Wenjin;Wang, Rui;Kong, Ziqing

作者机构:

关键词: antimicrobial peptide;polybia-CP;candidiasis;antifungal;ROS production

期刊名称:JOURNAL OF PEPTIDE SCIENCE ( 影响因子:1.905; 五年影响因子:2.244 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: The incidence of life-threatening invasive fungal infections increased significantly in recent years. However, the antifungal therapeutic options are very limited. Antimicrobial peptides are a class of potential lead chemical for the development of novel antifungal agents. Antimicrobial peptide polybia-CP was purified from the venom of the social wasp Polybia paulista. In this study, we synthesized polybia-CP and determined its antifungal effects against a series of Candidian species. Our results showed that polybia-CP has potent antifungal activity and fungicidal activity against the tested fungal cells with a proposed membrane-active action mode. In addition, polybia-CP could induce the increase of cellular reactive oxygen species production, which would attribute to its antifungal activity. In conclusion, the present study suggests that polybia-CP has potential as an antifungal agent or may offer a new strategy for antifungal therapeutic option. Copyright (c) 2015 European Peptide Society and John Wiley & Sons, Ltd.

分类号: Q516

  • 相关文献

[1]The in vitro, in vivo antifungal activity and the action mode of Jelleine-I against Candida species. Jia, Fengjing,Wang, Jiayi,Peng, Jinxiu,Zhao, Ping,Wang, Kairong,Yan, Wenjin,Wang, Rui,Kong, Ziqing. 2018

[2]D-amino acid substitution enhances the stability of antimicrobial peptide polybia-CP. Jia, Fengjing,Wang, Jiayi,Peng, Jinxiu,Zhao, Ping,Wang, Kairong,Yan, Wenjin,Wang, Rui,Kong, Ziqing. 2017

[3]Heterologous Expression of the Cotton NBS-LRR Gene GbaNA1 Enhances Verticillium Wilt Resistance in Arabidopsis. Li, Nan-Yang,Zhou, Lei,Zhang, Dan-Dan,Li, Ting-Gang,Gui, Yue-Jing,Kong, Zhi-Qiang,Ma, Xue-Feng,Zhang, Wen-Qi,Li, Jun-Jiao,Chen, Jie-Yin,Dai, Xiao-Feng,Klosterman, Steven J.,Short, Dylan P. G.,Subbarao, Krishna V.. 2018

[4]Syntheses, characterization and biological studies of zinc(II), copper(II) and cobalt(II) complexes with Schiff base ligand derived from 2-hydroxy-1-naphthaldehyde and selenomethionine. Ran, Xueguang,Wang, Lingyun,Cao, Derong,Ran, Xueguang,Lin, Yingcai,Hao, Jie. 2010

[5]Facile fabrication of graphene oxide loaded with silver nanoparticles as antifungal materials. Cui, Jianghu,Yang, Yunhua,Zheng, Mingtao,Liu, Yingliang,Xiao, Yong,Lei, Bingfu,Chen, Wei. 2014

[6]Synthesis, characterization and in vitro biological activity of cobalt(II), copper(II) and zinc(II) Schiff base complexes derived from salicylaldehyde and D, L-selenomethionine. Ran, Xueguang,Wang, Lingyun,Cao, Derong,Ran, Xueguang,Lin, Yingcai,Hao, Jie. 2011

[7]Dibenzo-alpha-pyrones: a new class of larvicidal metabolites against Aedes aegypti from the endophytic fungus Hyalodendriella sp Ponipodef12. Mao, Ziling,Lai, Daowan,Liu, Xunda,Fu, Xiaoxiang,Meng, Jiajia,Wang, Ali,Wang, Xiaohan,Sun, Weibo,Zhou, Ligang,Liu, Zhi Long,Liu, Yang.

[8]Complete genome sequence of Bacillus amyloliquefaciens L-S60, a plant growth-promoting and antifungal bacterium. Qin, Yuxuan,Han, Yuzhu,Zhang, Bao,Li, Pinglan,Yu, Yaqiong,Shang, Qingmao.

[9]Cellulose Anionic Hydrogels Based on Cellulose Nanofibers As Natural Stimulants for Seed Germination and Seedling Growth. Zhang, Hao,Luan, Qian,Tang, Hu,Huang, Fenghong,Xiang, Xia,Yang, Chen,Bao, Yuping,Yang, Minmin.

[10]Identification of cyclosporin C from Amphichorda felina using a Cryptococcus neoformans differential temperature sensitivity assay. Xu, Lijian,Li, Yan,Bills, Gerald F.,Xu, Lijian,Li, Yan,Biggins, John B.,Bowman, Brian R.,Verdine, Gregory L.,Gloer, James B.,Alspaugh, J. Andrew,Alspaugh, J. Andrew. 2018

[11]In vitro anti-aflatoxigenic effect and mode of action of cinnamaldehyde against aflatoxin B-1. Sun, Qi,Liu, Yang,Wang, Ling,Lu, Zhisong.

[12]Potential use of Lactobacillus casei AST18 as a bioprotective culture in yogurt. Li, Hongjuan,Liu, Lu,Zhang, Shuwen,Uluko, Hankie,Cui, Wenming,Lv, Jiaping. 2013

[13]Antifungal activities and effect of Lactobacillus casei AST18 on the mycelia morphology and ultrastructure of Penicillium chrysogenum. Li, Hongjuan,Zhang, Shuwen,Lu, Jing,Liu, Lu,Uluko, Hankie,Pang, Xiaoyang,Xue, Haixiao,Zhao, Lili,Kong, Fanhua,Lv, Jiaping,Sun, Yanjun. 2014

[14]Synthesis and Antifungal Activity of Novel 1,2,4-Triazole Derivatives Containing 1,2,3-Thiadiazole Moiety. Tan, Cheng-Xia,Weng, Jian-Quan,Liu, Xing-Hai,Zhao, Wei-Guang,Shi, Yan-Xia,Li, Bao-Ju.

[15]Antifungal activity of the osthol derivative JS-B against Phytophthora capsici. Wang, Chun-Mei,Guan, Wei,Fang, Shu,Chen, Hao,Li, You-Qin,Fan, Yong-Jian,Shi, Zhi-Qi,Wang, Chun-Mei,Guan, Wei,Fang, Shu,Chen, Hao,Li, You-Qin,Fan, Yong-Jian,Shi, Zhi-Qi,Wang, Chun-Mei,Guan, Wei,Fang, Shu,Chen, Hao,Li, You-Qin,Fan, Yong-Jian,Shi, Zhi-Qi,Cai, Chun. 2010

[16]Antifungal Efficacy of Phellodendron amurense Ethanol Extract against Trichophyton mentagrophytes in Rabbits. Xiao, C. W.,Ji, Q. A.,Wei, Q.,Liu, Y.,Bao, G. L.,Rajput, Z. I.. 2014

[17]Fengycin antibiotics isolated from B-FS01 culture inhibit the growth of Fusarium moniliforme Sheldon ATCC 38932. Hu, Liang Bin,Shi, Zhi Qi,Zhang, Ting,Yang, Zhi Min.

[18]Transgenic rice expressing a novel phytase-lactoferricin fusion gene to improve phosphorus availability and antibacterial activity. Deng Li-hua,Weng Lu-shui,Deng Xiang-yang,Xiao Guo-ying,Wang Zuo-ping,Fu Xi-qin,Xin Ye-yun. 2017

[19]Identification of a cysteine-rich antimicrobial peptide from salivary glands of the tick Rhipicephalus haemaphysaloides. Zhang, Houshuang,Zhang, Wenjie,Wang, Xinzhi,Zhou, Yongzhi,Wang, Na,Zhou, Jinlin. 2011

[20]Design and pharmacodynamics of recombinant NZ2114 histidine mutants with improved activity against methicillin-resistant Staphylococcus aureus. Chen, Huixian,Feng, Xingjun,Chen, Huixian,Mao, Ruoyu,Teng, Da,Wang, Xiumin,Hao, Ya,Wang, Jianhua,Chen, Huixian,Mao, Ruoyu,Teng, Da,Wang, Xiumin,Hao, Ya,Wang, Jianhua. 2017

作者其他论文 更多>>