mrskn7, a putative response regulator gene of Monascus ruber M7, is involved in oxidative stress response, development, and mycotoxin production

文献类型： 外文期刊

第一作者： Shao, Yanchun

作者： Shao, Yanchun;Chen, Fusheng;Yang, Sha;Zhang, Zhouwei;Zhou, Youxiang

作者机构：

关键词： citrinin;development;Monascus ruber;oxidative stress;response regulator

期刊名称：MYCOLOGIA （ 影响因子：2.696； 五年影响因子：3.089 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Skn7, a response regulator (RR), is associated with oxidative stress adaptation, hypo-osmotic stress response, fungicide sensitivity, cell wall biosynthesis, cell cycle regulation, sexual mating, and sporulation in many filamentous fungi and yeasts. In this study a Skn7-like protein gene mrskn7 (Monascus ruber skn7) was isolated, sequenced, and disrupted to investigate its function in M. ruber. Bioinformatics predicted that the deduced protein encoded by mrskn7 contained the conserved DNA-binding and signal-receiver domains similar to the Skn7-like protein structure in other filamentous fungi. The Delta mrskn7 strain produced fewer conidia and less mycotoxin, demonstrated increased sensitivity to peroxide but the same level of osmotic resistance to NaCl and glycerol with the wild type. Additionally, cleistothecia observed at different time point showed a different morphology between the wild-type and the Delta mrskn7 strain, suggesting the involvement of mrskn7 in sexual development of M. ruber. These results indicated that mrskn7 plays important roles in asexual and sexual development, the production of mycotoxin as well as regulation of oxidative stress signal in M. Tuber.

分类号： S432.4

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