Kinetic analysis of RNA editing of Newcastle disease virus P gene in the early period of infection

文献类型： 外文期刊

第一作者： Qiu, X.

作者： Qiu, X.;Fu, Q.;Meng, C.;Yu, S.;Zhan, Y.;Dong, L.;Ren, T.;Sun, Y.;Tan, L.;Song, C.;Han, X.;Ding, C.;Ding, C.

作者机构：

关键词： Newcastle disease virus;phosphoprotein;RNA editing;G insertion

期刊名称：ACTA VIROLOGICA （ 影响因子：1.162； 五年影响因子：1.255 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： As a paramyxovirus, Newcastle disease virus (NDV) has the ability to edit its P (phosphoprotein) gene to synthesize three kinds of viral protein (P, V and W). It is technically very difficult to differentiate P, V and W mRNAs, and little was known about NDV regulation of RNA-editing frequency. To investigate the rules of NDV RNA editing, the ratio of the P gene-derived transcripts (P, V and W) was determined by sequencing at different time points post-infection. The results showed unstable ratio of V and W mRNA at different time points, and the frequency of NDV editing was significantly increased at the early period of infection (P <0.05). Along with the increase in editing frequency, the levels of V and W transcripts were obviously increased at 8 and 10 hours post infection (hpi). In addition, it was shown that the number of inserted G residues in P-derived transcripts was not limited to one or two: +3G, +4G, +5G and even +9G transcripts were identified. Higher RNA editing frequency of NDV P gene occurred in the early period of infection, which may play a role in the process of viral infection.

分类号： R37

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