Protective Effects of Genistein and Puerarin against Chronic Alcohol-Induced Liver Injury in Mice via Antioxidant, Anti-inflammatory, and Anti-apoptotic Mechanisms

文献类型: 外文期刊

第一作者: Zhao, Liang

作者: Zhao, Liang;Wang, Yong;Guo, Xiaoxuan;Ji, Baoping;Zhou, Feng;Liu, Jia;Wang, Kai;Wu, Wei

作者机构:

关键词: isoflavones;liver damage;alcohol;inflammation;oxidative stress

期刊名称:JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY ( 影响因子:5.279; 五年影响因子:5.269 )

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收录情况: SCI

摘要: This study aimed to, investigate the protective effect of genistein or puerarin on chronic alcohol-induced liver injury in vivo and to explore the underlying mechanisms of hepatoprotective effects. Mice were administered genistein or puerarin (0.3 mmol kg(-1) body weight) and gastrically infused with 50% alcohol once per day for 5,weeks. Levels of serum transaminases, serum and hepatic lipids, hepatic antioxidant capacities, inflammation, apoptosis, and histopathological sections were analyzed. Results showed that genistein and puerarin exhibited similar effects in ameliorating alcohol-induced liver injury. However, genistein is more effective than puerarin in decreasing levels of malondialdehyde (1.05 +/- 0.0947 vs 1.28 +/- 0.213 nmol/mg pro, p < 0.05), tumor necrosis factor a (3.12 +/- 0.498 vs 3.82 +/- 0.277 pg/mg pro, p < 0.05), interleukin-6 (1.46 +/- 0.223 vs 1.88 +/- 0.309 pg/mg pro, p < 0:05), whereas puerarin is more effective than genistein in ameliorating serum activities or levels of alanine transaminase (35.8 +/- 3.95 vs 42.6 +/- 6.56 U/L, p < 0.05) and low-density lipoprotein cholesterol (1.12 +/- 0.160 vs 1.55 +/- 0.150 mmol/L, p < 0.05). In conclusion, both genistein and puerarin effectively alleviate hepatic damage induced by chronic alcohol administration through potential antioxidant, anti-inflammatory, or anti-apoptotic mechanisms.,

分类号: R15`S

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