Chemical constituents from Piper hainanense and their cytotoxicities

文献类型： 外文期刊

第一作者： Shi, Yan-Ni

作者： Shi, Yan-Ni;Xin, Ying;Ling, Yi;Zhu, Hong-Tao;Wang, Dong;Yang, Chong-Ren;Xu, Min;Zhang, Ying-Jun;Shi, Yan-Ni;Xin, Ying;Ling, Yi;Li, Xing-Cong;Hao, Chao-Yun

作者机构：

关键词： Piperaceae;Piper hainanense;cytotoxicity;polyoxygenated cyclohexene derivatives;benzene derivatives;pipoxide

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Two new compounds, (Z,R)-1-phenylethylcinnamate (1) and (1R,2R,3R,6S)-pipoxide (2) were isolated from the aerial part of Piper hainanense, along with 12 known compounds, including nine benzene derivatives (4-11), one isobutylamide (12), and two polyoxygenated cyclohexene derivatives (13-14). Their structures were elucidated on the basis of the HRESIMS, 1D and 2D NMR spectroscopic analyses, and ECD in cases of 2 and 3. The absolute configuration of ellipeiopsol B (3) was determined for the first time. All these compounds 1-14 were reported from the titled plant for the first time. Most of the isolates were tested for their cytotoxicities against five human cancer cell lines. Four of which, 2, 3, 9, 14 showed moderate bioactivities. Among them, the new compound 2 showed potential cytotoxicity against SMMC-7721, MCF-7, and SW-480 with IC50 values of 9.7, 15.0, and 13.2M, respectively.

分类号： R9

  • 相关文献

[1]Construction of a cDNA library and preliminary analysis of expressed sequence tags in Piper hainanense. Fan, R.,Ling, P.,Hao, C. Y.,Li, F. P.,Huang, L. F.,Wu, B. D.,Wu, H. S.,Fan, R.,Huang, L. F.,Wu, H. S.,Hao, C. Y.,Li, F. P.,Wu, B. D.,Ling, P.. 2015

[2]Fabrication and stabilization of biocompatible selenium nanoparticles by carboxylic curdlans with various molecular properties. Yan, Jing-Kun,Qiu, Wen-Yi,Wang, Yao-Yao,Wang, Wen-Han,Yang, Yan,Zhang, He-Nan,Wang, Wen-Han,Yang, Yan,Zhang, He-Nan. 2018

[3]Anti-Phytopathogenic and Cytotoxic Activities of Crude Extracts and Secondary Metabolites of Marine-Derived Fungi. Zhao, Dong-Lin,Wang, Dan,Tian, Xue-Ying,Li, Yi-Qiang,Zhang, Cheng-Sheng,Cao, Fei. 2018

[4]Optimization of Catechin Nanoliposomes and Evaluation of Their Antioxidant Activity and Cytotoxicity. Wu, Zhipan,Guan, Rongfa,Liu, Mingqi,Xiao, Chaogeng,Lyu, Fei,Cao, Guozhou,Gao, Jianguo. 2017

[5]Cytotoxicity, oxidative stress, and genotoxicity in human hepatocyte and embryonic kidney cells exposed to ZnO nanoparticles. Guan, Rongfa,Kang, Tianshu,Liu, Mingqi,Lu, Fei,Zhang, Zhiguo,Shen, Haitao. 2012

[6]A new drimane sesquiterpenoid glycoside from the seeds of Antiaris toxicaria. Dong, Wen-Hua,Mei, Wen-Li,Zhao, You-Xing,Zeng, Yan-Bo,Wang, Hui,Dai, Hao-Fu,Dong, Wen-Hua,Mei, Wen-Li,Zhao, You-Xing,Zeng, Yan-Bo,Wang, Hui,Dai, Hao-Fu. 2011

[7]Dimeric sesquiterpenoid-4&ITH&IT-chromone derivatives from agarwood of &ITAquilaria crassna&IT and their cytotoxicity. Yang, Yang,Chen, Hui-Qin,Kong, Fan-Dong,Zhou, Li-Man,Li, Wei,Dong, Wen-Hua,Mei, Wen-Li,Dai, Hao-Fu,Yang, Yang,Chen, Zhi-Bao. 2018

[8]Screening of microorganisms from Antarctic surface water and cytotoxicity metabolites from Antarctic microorganisms. Zheng, Lanhong,Yang, Kangli,Sun, Mi,Zhu, Jiancheng,Lv, Mei,Kang, Daole,Wang, Wei,Xing, Mengxin,Li, Zhao,Liu, Jia. 2016

[9]Cytotoxicity and genotoxicity of 1,4-bisdesoxyquinocetone, 3-methylquinoxaline-2-carboxylic acid (MQCA) in human hepatocytes. Zhang, Keyu,Ban, Manman,Zheng, Haihong,Wang, Xiaoyang,Wang, Mi,Fei, Chenzhong,Xue, Feiqun,Zhao, Zhanzhong. 2012

[10]Ustiloxin G, a New Cyclopeptide Mycotoxin from Rice False Smut Balls. Wang, Xiaohan,Wang, Jian,Lai, Daowan,Wang, Weixuan,Zhou, Ligang,Dai, Jungui,Dai, Jungui,Liu, Yang. 2017

[11]Preparation and immunological effectiveness of a Swine influenza DNA vaccine encapsulated in PLGA microspheres. Li, Guo-Xin,Tong, Guang-Zhi,Zhao, Kai,Jin, Yuan-Yuan,Wei, Hai-Xia,Sun, Qing-Shen,Huang, Ting-Ting,Zhao, Kai,Jin, Yuan-Yuan,Wei, Hai-Xia,Huang, Ting-Ting,Wang, Yun-Feng,Tong, Guang-Zhi. 2010

[12]New Xanthone from the Pericarp of Garcinia mangostana. Fu, Manqin,Xu, Yujuan,Wu, Jijun,Chen, Yulong,Yu, Yuanshan,Xiao, Gengsheng,Qiu, Samuel X.. 2013

[13]A new cytotoxic iridoid from Callicarpa nudiflora. Mei, Wen-Li,Han, Zhuang,Cui, Hai-Bin,Deng, Yuan-Yuan,Dai, Hao-Fu,Zhao, You-Xing. 2010

[14]New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells. Yuan, Ganjun,Yuan, Ganjun,Hong, Kui,Lin, Haipeng,Yuan, Ganjun,Hong, Kui,She, Zhigang,Li, Jia. 2013

[15]Cytotoxicity and Apoptosis Induction of Bovine Alpha-lactalbumin-oleic Acid Complex in Human Breast Cancer Cells. Zhong, Saiyi,Chen, Suhua,Zhou, Siyi,Qin, Xiaoming,Wang, Weimin,Liu, Shouchun,Liu, Hai.

[16]Endogenous expression of a Bt toxin receptor in the Cry1Ac-susceptible insect cell line and its synergistic effect with cadherin on cytotoxicity of activated Cry1Ac. He, Fei,Li, Jianghuai,Yang, Yongbo,Ai, Hui,Peng, Jianxin,Hong, Huazhu,Liu, Kaiyu,Xiao, Yutao,Liu, Chenxi.

[17]Chemical composition, antimicrobial activity against Staphylococcus aureus and a pro-apoptotic effect in SGC-7901 of the essential oil from Toona sinensis (A. Juss.) Roem. leaves. Wu, Jian-Guo,Wu, Yan-Bin,Wu, Jin-Zhong,Peng, Wei,Yi, Jun,Chen, Ti-Qiang,Wong, Ka-Hing. 2014

[18]Cytotoxic and Antibacterial Flavonoids from Dragon's Blood of Dracaena cambodiana. Luo, Ying,Wang, Hui,Zhao, You-Xing,Zeng, Yan-Bo,Shen, Hai-Yan,Dai, Hao-Fu,Mei, Wen-Li,Wang, Hui,Zhao, You-Xing,Zeng, Yan-Bo,Dai, Hao-Fu,Mei, Wen-Li. 2011

[19]Study on the Chemical Constituents from the Latex of Antiaris toxicaria. Mei Wenli,Gan Yujuan,Que Dongmei,Li Xiaona,Dai Haofu. 2011

[20]Structure Elucidation of Flavonoids from Antiaris toxicaria Roots. Que Dongmei,Mei Wenli,Wu Jiao,Han Zhuang,Dai Haofu. 2009

作者其他论文 更多>>

微信小程序