Secondary metabolites from marine-derived Streptomyces antibioticus strain H74-21

文献类型： 外文期刊

第一作者： Fu, Shuna

作者： Fu, Shuna;Wang, Fan;Li, Hongyu;Bao, Yixuan;Yang, Yu;Zhou, Guangxiong;Shen, Huifang;Lin, Birun

作者机构：

关键词： Streptomycete;secondary metabolites;dipeptide;streptomyceamide C;piperidinedione

期刊名称：NATURAL PRODUCT RESEARCH （ 影响因子：2.861； 五年影响因子：2.572 ）

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年卷期：

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收录情况： SCI

摘要： A new secondary metabolite, (2S,3R)-l-threonine, N-[3-(formylamino)-2-hydroxybenzoyl]-ethyl ester (streptomyceamide C, 1), together with four known compounds 1, 4-dimethyl-3-isopropyl-2,5-piperidinedione (2), cyclo-((S)-Pro-8- hydroxy-(R)-Ile (3), cyclo-((S)-Pro-(R)-Leu (4), and seco-((S)-Pro-(R)-Val) (5), were isolated from the EtOH extract of the fermented mycelium of the marine-derived streptomycete strain H74-21, which was isolated from sea sediment in a mangrove site. The structure of the new compound was established on the basis of its spectroscopic data, including 1D and 2D NMR, HR-TOF-MS. Their antifungal activities against Candida albicans and cytotoxicities against human breast adenocarcinoma cell line MCF-7, human glioblastoma cell line SF-268 and human lung cancer cell line NCI-H460 were tested. Compounds 1 only displayed cytotoxicity against human breast adenocarcinoma cell line MCF-7 with the IC50 value of 27.0g/mL. However, compounds 1-5 do not show antifungal activities at the test concentration of 1mg/mL, and 2-5 have no cytotoxicities at the test concentration of 50g/mL.

分类号： R9

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