Effect of alpha-lipoic acid on relieving ammonia stress and hepatic proteomic analyses of broilers

文献类型： 外文期刊

第一作者： Lu, M.

作者： Lu, M.;Yin, Q. Q.;Lu, M.;Bai, J.;Xu, B.;Sun, Q. Y.;Wei, F. X.;Li, J.;Wang, G. L.;Li, S. Y.;Tang, X. F.;Zhang, H. F.

作者机构：

关键词： alpha-lipoic acid;ammonia stress;broiler;proteomics;production performance

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Ammonia in poultry houses not only affects worker health but also induces a variety of poultry diseases. Alpha-lipoic acid (LA) is an effective antioxidant that protects cells against oxidative injury during various toxic and pathological processes. This study was designed to evaluate the mitigating effects of LA supplementation on ammonia stress and hepatic proteome changes in broilers. Male broilers (22 d old) were allocated to 3 groups: (1) a control group without ammonia stress (CTRL); (2) exposure to 70 ppm ammonia (AM); and (3) exposure to 70 ppm ammonia and dietary administration of 300 mg/kg LA (AM+LA). Ammonia exposure significantly decreased broiler growth performance and plasma glutathione peroxidase activity (P < 0.05), and increased plasma malondialdehyde content and glutamic-pyruvic transaminase activity (P < 0.05). These negative effects were eliminated by LA supplementation. Comparative proteomic analyses revealed 291 differentially expressed proteins in the AM group compared to the CTRL and AM+LA groups. A total of 30 proteins were differentially expressed between the AM/CTRL and (AM+LA)/AM groups. The addition of LA restored 24 of these proteins to control levels; these proteins were mainly related to transcription regulation, detoxification, protein translation and degradation, and immune and stress responses. The differentially expressed proteins included the high mobility group box (HMGB) and glutathione S-transferase (GST), which is closely related to immune response and oxidative stress, and collagens, which are implicated in liver injury. The addition of LA to broiler diet may reduce ammonia toxicity by maintaining the antioxidant system, xenobiotic metabolism, and metabolic pathways.

分类号： S8

  • 相关文献

[1]Effects of alpha-lipoic acid supplementation on growth performance, antioxidant capacity and biochemical parameters for ammonia-exposed broilers. Lu, Min,Bai, Jie,Wei, Fengxian,Xu, Bin,Sun, Quanyou,Li, Jie,Wang, Gaili,Yin, Qingqiang,Lu, Min,Li, Shaoyu,Tang, Xiangfang,Zhang, Hongfu.

[2]Effects of dietary vitamin C, vitamin E, and alpha-lipoic acid supplementation on the antioxidant defense system and immune-related gene expression in broilers exposed to oxidative stress by dexamethasone. El-Senousey, H. K.,Chen, B.,Wang, J. Y.,Nie, Q. H.,El-Senousey, H. K.,Chen, B.,Wang, J. Y.,Nie, Q. H.,El-Senousey, H. K.,Atta, A. M.. 2018

[3]Differential expression analysis of the broiler tracheal proteins responsible for the immune response and muscle contraction induced by high concentration of ammonia using iTRAQ-coupled 2D LC-MS/MS. Xiong, Yan,Tang, Xiangfang,Meng, Qingshi,Zhang, Hongfu. 2016

[4]Effect of dietary Clostridium butyricum on growth, intestine health status and resistance to ammonia stress in Pacific white shrimp Litopenaeus vannamei. Duan, Yafei,Zhang, Yue,Dong, Hongbiao,Wang, Yun,Zheng, Xiaoting,Zhang, Jiasong.

[5]Flaxseed oil and alpha-lipoic acid combination reduces atherosclerosis risk factors in rats fed a high-fat diet. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Yang, Wei. 2012

[6]Effects of dietary alpha-lipoic acid on carcass characteristics, antioxidant capability and meat quality in Hainan black goats. Wang, Dingfa,Zhou, Luli,Zhou, Hanlin,Hou, Guanyu,Shi, Liguang. 2017

[7]Flaxseed oil and alpha-lipoic acid combination ameliorates hepatic oxidative stress and lipid accumulation in comparison to lard. Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Xu, Jiqu,Deng, Qianchun,Huang, Qingde,Yang, Jin'e,Huang, Fenghong,Gao, Hui,Yang, Wei,Song, Lin,Chen, Chang. 2013

[8]Effects of Yeast Polysaccharide on Immune Enhancement and Production Performance of Rats. Wang, Hui,Cheng, Fu-Sheng,Luo, Yong-Jiang,Dong, Peng-Cheng,Wang, Hui,Zhang, Xia. 2012

[9]Effect of feed consumption levels on growth performance and carcass composition during the force-feeding period in foie gras production of male Mule ducks. Wen, Z. G.,Jiang, Y.,Tang, J.,Xie, M.,Hou, S. S.,Wen, Z. G.,Yang, P. L.,Jiang, Y.,Tang, J..

[10]Association of polymorphisms of Nramp1 gene with immune function and production performance of large white pig. Wu, Hongmei,Cheng, Duxue,Wang, Lixian. 2008

[11]Effects of dietary fat levels on nutrient digestibility and production performance of growing-furring blue foxes (Alopex lagopus). Geng, Y. Y.,Gao, X. H.,Yang, F. H.,Xing, X. M.,Yang, F. H.,Xing, X. M.. 2012

[12]Auto-induction-based Rapid Evaluation of Extracellular Enzyme Expression from Lac Operator-involved Recombinant Escherichia coli. Chen, Wen-Bo,Nie, Yao,Mu, Xiao-Qing,Yan, Wei,Xu, Yan,Chen, Wen-Bo,Nie, Yao,Mu, Xiao-Qing,Yan, Wei,Xu, Yan,Chen, Wen-Bo,Xu, Yan,Xiao, Rong.

[13]Feeding different dietary protein to energy ratios to Holstein heifers: effects on growth performance, blood metabolites and rumen fermentation parameters. Dong, L. F.,Zhang, W. B.,Zhang, N. F.,Tu, Y.,Diao, Q. Y..

[14]Effects of Three Feeding Systems on Production Performance, Rumen Fermentation and Rumen Digesta Particle Structure of Beef Cattle. Sun, F. F.,Liu, Y. F.,Wan, F. C.,Zhao, H. B.,Liu, X. M.,You, W.,Cheng, H. J.,Liu, G. F.,Tan, X. W.,Song, E. L..

[15]Effects of high temperature on multiple parameters of broilers in vitro and in vivo. Feng, J.,Zhang, M.,Zheng, S.,Xie, P.,Ma, A.. 2008

[16]Expression of heat shock protein 70 in transport-stressed broiler pectoralis major muscle and its relationship with meat quality. Xing, T.,Han, M. Y.,Xu, X. L.,Zhou, G. H.,Wang, M. F.,Zhu, X. S.. 2017

[17]One size fits all? Contract farming among broiler producers in China. Huang Ze-ying,Wang Chen,Wang Ji-min,Xu Ying,Zeng Di. 2018

[18]Growth Performance, Intestinal Histomorphology, Blood Hematology and Serum Metabolites of Broilers Chickens Fed Diet Supplemented with Graded Levels of Acetic Acid. Ur Rehman, Zaib,Ul Haq, Ahsan,Akram, Naasra,Saeed, Muhammad,Rehman, Shahid Ur,Abd El-Hack, Mohamed E.,Alagawany, Mahmoud,Ur Rehman, Zaib,Meng, Chunchun,Ding, Chan,Sayab, Maryam,Dhama, Kuldeep. 2016

[19]Effects of outdoor access on growth performance, carcass composition, and meat characteristics of broiler chickens. Chen, X.,Jiang, W.,Xu, G. F.,Zhang, X. B.,Wang, X. Q.,Tan, H. Z.,Wei, S.. 2013

[20]Overexpression of heat shock protein 70 and its relationship to intestine under acute heat stress in broilers: 2. Intestinal oxidative stress. Gu, X. H.,Hao, Y.,Wang, X. L.. 2012

作者其他论文 更多>>

微信小程序