ALV-J strain SCAU-HN06 induces innate immune responses in chicken primary monocyte-derived macrophages

文献类型： 外文期刊

第一作者： Feng, Min

作者： Feng, Min;Tan, Yan;Li, Zhenhui;Zhang, Xiquan;Feng, Min;Tan, Yan;Li, Zhenhui;Zhang, Xiquan;Feng, Min;Tan, Yan;Li, Zhenhui;Zhang, Xiquan;Dai, Manman;Cao, Weisheng;Shi, Meiqing

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关键词： ALV-J;macrophage;innate immune response

期刊名称：POULTRY SCIENCE （ 影响因子：3.352； 五年影响因子：3.679 ）

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收录情况： SCI

摘要： Avian leucosis virus subgroup J (ALV-J) can cause lifelong infection and can escape from the host immune defenses in chickens. Since macrophages act as the important defense line against invading pathogens in host innate immunity, we investigated the function and innate immune responses of chicken primary monocyte-derived macrophages (MDM) after ALV-J infection in this study. Our results indicated that ALV-J was stably maintained in MDM cells but that the viral growth rate was significantly lower than that in DF-1 cells. We also found that ALV-J infection significantly increased nitric oxide (NO) production, but had no effect on MDM phagocytic capacity. Interestingly, infection with ALV-J rapidly promoted the expression levels of Myxovirus resistance 1 (Mx) (3 h, 6 h), ISG12 (6 h), and interleukin-1 beta (IL-1 beta) (3 h, 12 h) at an early infection stage, whereas it sharply decreased the expression of Mx (24 h, 36 h), ISG12 (36 h), and made little change on IL-1 beta (24 h, 36 h) production at a late infection stage in MDM cells. Moreover, the protein levels of interferon-beta (IFN-beta) and interleukin-6 (IL-6) had sharply increased in infected MDM cells from 3 to 36 h post infection (hpi) of ALV-J. And, the protein level of interleukin-10 (IL-10) was dramatically decreased at 36 hpi in MDM cells infected with ALV-J. These results demonstrate that ALV-J can induce host innate immune responses and we hypothesize that macrophages play an important role in host innate immune attack and ALV-J immune escape.

分类号： S8

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