Anti-diabetic effects of soluble and insoluble dietary fibre from deoiled cumin in low-dose streptozotocin and high glucose-fat diet-induced type 2 diabetic rats

文献类型： 外文期刊

第一作者： Ma, Mengmei

作者： Ma, Mengmei;Mu, Taihua

作者机构：

关键词： Type 2 diabetic rat;Deoiled cumin;Dietary fibre;Biochemical parameters;Histopathological analysis

期刊名称：JOURNAL OF FUNCTIONAL FOODS （ 影响因子：4.451； 五年影响因子：4.907 ）

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收录情况： SCI

摘要： The effects of soluble dietary fibre (SDF) and insoluble dietary fibre (IDF) from deoiled cumin on low-dose streptozotocin and high glucose-fat-induced type 2 diabetes rats were examined. Male Wistar rats were divided into nine groups: control (non-diabetic, no SDF or IDF intake), model (diabetes only), metformin, high-dose SDF (5 g/kg body weight), middle dose SDF (500 mg/kg body weight), low-dose SDF (250 mg/kg body weight), high-dose IDF (5 g/kg body weight), middle-dose IDF (500 mg/kg body weight), and low-dose IDF (250 mg/kg body weight). SDF treatments, in particular, middle-dose SOF for 4 weeks, induced better regulation of blood glucose, insulin, hormones, and liver lipid metabolism in diabetic rats, accompanied by increased levels of short-chain fatty acids in colon and decreased fatty degeneration of liver. Our results collectively support the therapeutic potential of SDF from deoiled cumin in type 2 diabetes. (C) 2016 Published by Elsevier Ltd.

分类号： TS2

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