Exploring the molecular mechanism of acute heat stress exposure in broiler chickens using gene expression profiling

文献类型： 外文期刊

第一作者： Luo, Q. B.

作者： Luo, Q. B.;Zhang, X. Q.;Zhang, D. X.;Luo, Q. B.;Song, X. Y.;Zhang, X. Q.;Ji, C. L.;Zhang, D. X.

作者机构：

关键词： Chicken;Heat-stress response;Gene expression;Gene module

期刊名称：GENE （ 影响因子：3.688； 五年影响因子：3.329 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The process of heat regulation is complex and its exact molecular mechanism is not fully understood. In this study, to investigate the global gene regulation response to acute heat exposure, gene microarrays were exploited to analyze the effects of heat stress on three tissues (brain, liver, leg muscle) of the yellow broiler chicken (Gallus gallus). We detected 166 differentially expressed genes (DEGs) in the brain, 219 in the leg muscle and 317 in the liver. Six of these genes were differentially expressed in all three tissues and were validated by qRT-PCR, and included heat shock protein genes (HSPH1, HSP25), apoptosis-related genes (RB1CC1;BAG3), a cell proliferation and differentiation-related gene (ID1) and the hunger and energy metabolism related gene (PDK). All these genes might be important factors in chickens suffering from heat stress. We constructed gene co-expression networks using the DEGs of the brain, leg muscle and liver and two, four and two gene co-expression modules were identified in these tissues, respectively. Functional enrichment of these gene modules revealed that various functional clusters were related to the effects of heat stress, including those for cytoskeleton, extracellular space, ion binding and energy metabolism. We concluded that these genes and functional clusters might be important factors in chickens under acute heat stress. Further in-depth research on the newly discovered heat-related genes and functional clusters is required to fully understand their molecular functions in thermoregulation. (C) 2014 Elsevier B.V. All rights reserved.

分类号： R394

  • 相关文献

[1]Expression patterns of NLRC5 and key genes in the STAT1 pathway following infection with Salmonella pullorum. Qiu, Lingling,Ma, Teng,Chang, Guobin,Guo, Xiaomin,Xu, Lu,Zhang, Yang,Zhao, Wenming,Xu, Qi,Chen, Guohong,Liu, Xiangping.

[2]Dynamic Expression of Genes Related to Feed Intake in Broilers Regulated by Aging and Fasting Conditions. Ban, Qian,Liu, Dahai,Cheng, Fei,Hui, Wenqiao,Liu, Xiaojun,Liu, Xiaojun.

[3]The regulation of IMF deposition in pectoralis major of fast- and slow- growing chickens at hatching. Liu, Lu,Cui, Huanxian,Fu, Ruiqi,Zheng, Maiqing,Liu, Ranran,Zhao, Guiping,Wen, Jie,Liu, Lu,Cui, Huanxian,Fu, Ruiqi,Zheng, Maiqing,Liu, Ranran,Zhao, Guiping,Wen, Jie. 2017

[4]Molecular cloning and expression analysis of TRAF3 in chicken. Yang, H. L.,Feng, Z. Q.,Zeng, S. Q.,Zhu, Q.,Liu, Y. P.,Li, S. M.. 2015

[5]Expression of variant transcripts of the potassium channel tetramerization domain-containing 15 (KCTD15) gene and their association with fatness traits in chickens. Liang, S. S.,Ouyang, H. J.,Liu, J.,Chen, B.,Nie, Q. H.,Zhang, X. Q.,Liang, S. S.,Ouyang, H. J.,Liu, J.,Chen, B.,Nie, Q. H.,Zhang, X. Q.,Liang, S. S.,Ouyang, H. J.,Liu, J.,Chen, B.,Nie, Q. H.,Zhang, X. Q..

[6]Molecular cloning and functional characterization of a novel isoform of chicken myeloid differentiation factor 88 (MyD88). Qiu, Yafeng,Shen, Yang,Li, Xiangdong,Ding, Chan,Ma, Zhiyong.

[7]Deep Sequencing Analysis of miRNA Expression in Breast Muscle of Fast-Growing and Slow-Growing Broilers. Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan. 2015

[8]Molecular epidemiology of hydropericardium syndrome outbreak-associated serotype 4 fowl adenovirus isolates in central China. Zhang, Teng,Zhang, Teng,Jin, Qianyue,Ding, Peiyang,Chai, Yongxiao,Li, Yafei,Liu, Xiao,Luo, Jun,Zhang, Gaiping,Chai, Yongxiao,Liu, Xiao,Zhang, Gaiping,Ding, Peiyang,Li, Yafei,Wang, Yinbiao,Jin, Qianyue,Zhang, Gaiping. 2016

[9]A premature stop codon within the tvb receptor gene results in decreased susceptibility to infection by avian leukosis virus subgroups B, D, and E. Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Li, Aijun,Shu, Dingming,Zhang, Huanmin,Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Chen, WeiGuo,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei. 2017

[10]Differential expression of L-FABP and L-BABP between fat and lean chickens. Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Wang, Q.,Li, H.,Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Li, H.,Wang, Q.. 2013

[11]An association between genetic variation in the roundabout, axon guidance receptor, homolog 2 gene and immunity traits in chickens. Shu, D. M.. 2014

[12]Differentially expressed genes in the liver of lean and fat chickens. He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Li, H.,Wang, Q. G.. 2014

[13]A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming. 2014

[14]Biological Characteristics of Chinese Precocious Strain of Eimeria acervulina and Its Immune Efficacy Against Different Field Strains. Wu, Lin-Lin,Lin, Rui-Qing,Duan, Wen-Fang,Zou, Shang-Shu,Yuan, Zi-Guo,Weng, Ya-Biao,Sun, Ming-Fei,Liu, Li-Dan. 2014

[15]Determination of virginiamycin M1 residue in tissues of swine and chicken by ultra-performance liquid chromatography tandem mass spectrometry. Wang, Xiaoyang,Wang, Mi,Zhang, Keyu,Hou, Ting,Zhang, Lifang,Fei, Chenzong,Xue, Feiqun,Wang, Xiaoyang,Hang, Taijun. 2018

[16]Up-regulation of NLRC5 and NF-kappa B signaling pathway in carrier chickens challenged with Salmonella enterica Serovar Pullorum at different persistence periods. Liu, Xiangping,Sheng, Zhongwei,Dou, Xinhong,Wang, Kehua,Ma, Teng,Wang, Hongzhi,Li, Zhiteng,Pan, Zhiming,Chang, Guobin,Chen, Guohong. 2015

[17]Dissection of Myogenic Differentiation Signatures in Chickens by RNA-Seq Analysis. Li, Tingting,Zhang, Genxi,Wu, Pengfei,Liu, Qiuhong,Wang, Jinyu,Duan, Lian,Li, Guohui. 2018

[18]Combination of multi-element and stable isotope analysis improved the traceability of chicken from four provinces of China. Zhao, Yan,Wang, Donghua,Yang, Shuming,Zhao, Yan,Wang, Donghua,Yang, Shuming,Zhang, Bin,Guo, Bin,Guo, Bin. 2016

[19]Complete mitochondrial genome sequence and gene organization of Chinese indigenous chickens with phylogenetic considerations. Zhao, F. P.,Zhang, B. K.,Zhao, F. P.,Fan, H. Y.,Fan, H. Y.,Li, G. H.. 2016

[20]Detecting Splicing Variants of FOXP2 and its Protein Expression in Chicken Brain. Wang, Xi,Hamid, Mohammod Abdul,Zhao, Xingbo,Wang, Xi,Li, Hongxia. 2012

作者其他论文 更多>>

微信小程序