Magnetic nanoparticles are highly toxic to chloroquine-resistant Plasmodium falciparum, dengue virus (DEN-2), and their mosquito vectors
文献类型: 外文期刊
第一作者: Murugan, Kadarkarai
作者: Murugan, Kadarkarai;Paulpandi, Manickam;Samidoss, Christina Mary;Dinesh, Devakumar;Chandramohan, Balamurugan;Subramaniam, Jayapal;Vadivalagan, Chithravel;Amuthavalli, Pandiyan;Jaganathan, Anitha;Wei, Jiang;Alsalhi, Mohamad Saleh;Devanesan, Sandhanasamy;Nicoletti, Marcello;Paneerselvam, Chellasamy;Aziz, Al Thabiani;Wei, Hui;Higuchi, Akon;Kumar, Suresh;Nataraj, Devaraj;Vaseeharan, Baskaralingam;Canale, Angelo;Benelli, Giovanni
作者机构:
关键词: Antiviral activity;Malaria;Magnetospirillum gryphiswaldense;Magnetotactic bacteria;Yellow fever;Zika virus
期刊名称:PARASITOLOGY RESEARCH ( 影响因子:2.289; 五年影响因子:2.403 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: A main challenge in parasitology is the development of reliable tools to prevent or treat mosquito-borne diseases. We investigated the toxicity of magnetic nanoparticles (MNP) produced by Magnetospirillum gryphiswaldense (strain MSR-1) on chloroquine-resistant (CQ-r) and sensitive (CQ-s) Plasmodium falciparum, dengue virus (DEN-2), and two of their main vectors, Anopheles stephensi and Aedes aegypti, respectively. MNP were studied by Fourier-transform infrared spectroscopy and transmission electron microscopy. They were toxic to larvae and pupae of An. stephensi, LC50 ranged from 2.563 ppm (1st instar larva) to 6.430 ppm (pupa), and Ae. aegypti, LC50 ranged from 3.231 ppm (1st instar larva) to 7.545 ppm (pupa). MNP IC50 on P. falciparum were 83.32 mu g ml(-1) (CQ-s) and 87.47 mu g ml(-1) (CQ-r). However, the in vivo efficacy of MNP on Plasmodium berghei was low if compared to CQ-based treatments. Moderate cytotoxicity was detected on Vero cells post-treatment with MNP doses lower than 4 mu g ml(-1). MNP evaluated at 2-8 mu g ml(-1) inhibited DEN-2 replication inhibiting the expression of the envelope (E) protein. In conclusion, our findings represent the first report about the use of MNP in medical and veterinary entomology, proposing them as suitable materials to develop reliable tools to combat mosquito-borne diseases.
分类号: R53
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