Simultaneous determination of anabolic steroids and beta-agonists in milk by QuEChERS and ultra high performance liquid chromatography tandem mass spectrometry

文献类型： 外文期刊

第一作者： Liu, Hongcheng

作者： Liu, Hongcheng;Lin, Tao;Li, Ning;Wang, Luxiang;Li, Qiwan;Liu, Hongcheng;Lin, Tao;Li, Ning;Wang, Luxiang;Li, Qiwan;Liu, Hongcheng;Lin, Tao;Li, Ning;Wang, Luxiang;Li, Qiwan;Cheng, Xianglei;Li, Ning

作者机构：

关键词： Anabolic steroids;beta-Agonists;QuEChERS;ZnO nanoparticles;UHPLC-MS-MS

期刊名称：JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES （ 影响因子：3.205； 五年影响因子：3.068 ）

ISSN：

年卷期：

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收录情况： SCI

摘要： A simple, accurate and highly sensitive multiresidues method was developed for the determination of 9 anabolic steroids and 16 beta-agonists in milk. Target compounds were extracted and separated by a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) method with Primary secondary amine (PSA) and Zinc oxide (ZnO) nanoparticles as adsorbents. The analytes were determined by ultra high performance liquid chromatography coupled to an electro-spray ionization tandem mass spectrometer (UHPLC-MS/MS) operating in negative/positive multiple reaction monitoring mode. The effect of QuECh-ERS including organic solvent, amount of ZnO nanoparticle was evaluated. Good linearity was obtained for the analytes in the concentration range of 0.1-200 mu g/L with a correlation coefficients higher than 0.994. Decision limits (CC alpha) was from 0.007 mu g/kg-0.1 mu g/kg, and detection capabilities (CC beta) was in the range of 0.02-0.4 mu g/kg. The recoveries of these compounds were between 63% and 126% at three fortified levels. Reproducibility represented by RSD was with 10% or less. The method was successfully applied to screening of real milk samples obtained from local markets and confirmation of the suspected target analytes. (C) 2016 Elsevier B.V. All rights reserved.

分类号： Q503

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