Antioxidant and anti-hyperlipidemic effects of mycelia zinc polysaccharides by Pleurotus eryngii var. tuoliensis

文献类型： 外文期刊

第一作者： Xu, Nuo

作者： Xu, Nuo;Wang, Shouxian;Xu, Nuo;Ren, Zhenzhen;Zhang, Jianjun;Song, Xinling;Gao, Zheng;Jing, Huijuan;Li, Shangshang;Jia, Le

作者机构：

关键词： Zinc polysaccharides;Pleurotus eryngii var. tuoliensis;Antioxidant effects;Antihyperlipidemic effects

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

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收录情况： SCI

摘要： The aims of this work were designed to investigate the hepatoprotective and antioxidant effects of acidic- and alkali-extractable mycelia zinc polysaccharides (AcMZPS, AIMZPS) from Pleurotus eryngii var. tuoliensis on high-fat-high-cholesterol emulsion-induced hyperlipidemic mice. The in vivo experiments demonstrated that both AcMZPS and AIMZPS had potential hepatoprotective effects by significantly decreasing the levels of LDL-C, VLDL-C, TC, TG, ALT, AST, ALP, MDA and LPO, and remarkably increasing the HDL-C, SOD, GSH-Px, and CAT in serum lipid/liver homogenate, respectively. In addition, four polysaccharide fractions of AcMZPS-1, AcMZPS-2, AIMZPS-1, and AIMZPS-2, purified from AcMZPS and AIMZPS using DEAE chromatography, respectively, were subjected to monosaccharide composition analysis and valuated for the in vitro antioxidant activity. The results obtained in present study suggested that AcMZPS, AIMZPS and their purified fractions could be used as functional foods and natural drugs in preventing the hyperlipidemia and non-alcoholic fatty liver. (C) 2016 Elsevier B.V. All rights reserved.

分类号： Q71

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