Enantioselective metabolism and enantiomerization of benalaxyl in mice

文献类型： 外文期刊

第一作者： Wang, Xinru

作者： Wang, Xinru;Wang, Xinru;Zhu, Wentao;Wang, Dezhen;Zhou, Zhiqiang;Qiu, Jing

作者机构：

关键词： Benalaxyl;Enantioselectivity;Metabolism;Enantiomerization;Mice

期刊名称：CHEMOSPHERE （ 影响因子：7.086； 五年影响因子：6.956 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： The enantiomerization and enantioselective metabolism of benalaxyl in mice after a single gavage administration were investigated in the present study. The pharmacokinetic result indicated that elimination of (-)-R-benalaxyl in plasma was slightly faster with the t(1/2) of 26.65 h and 28.88 h for (-)-R- and (+)-S-benalaxyl, respectively. Consistent with this, elimination in tissues and excretion were also enantioselective, with (+)-S-benalaxyl enriched in all tissues, urine and feces. And formation of the metabolites also exhibited an enantioselective manner. Both benalaxyl and most of its metabolites exhibited a potent excretion to feces and urine. In addition, significant enantiomerization of benalaxyl enantiomers was observed in plasma, with a larger extent from R to S than S to R. Thus, this difference in enantiomerization may be one of the reasons to explain the enantioselective enrichment of (+)-S-benalaxyl in mice observed in this study. Data from this study proves that besides metabolic enzymes, enantiomerization could be another important factor that contributes to the enantioselective metabolism of a chiral pesticide. Thus, research at enantiomeric level is necessary for efficient risk assessment of chiral pesticides. (C) 2016 Published by Elsevier Ltd.

分类号： X5

  • 相关文献

[1]Evaluating the enantioselective degradation and novel metabolites following a single oral dose of metalaxyl in mice. Zhang, Ping,Zhu, Wentao,Wang, Dezhen,Wang, Xinru,Wang, Yao,Zhou, Zhiqiang,Qiu, Jing.

[2]Effects of chromium-enriched Bacillus subtilis KT260179 supplementation on growth performance, caecal microbiology, tissue chromium level, insulin receptor expression and plasma biochemical profile of mice under heat stress. Yang, Jiajun,Xu, Yayuan,Qian, Kun,Zhang, Wei,Wu, Dong,Wang, Chonglong.

[3]Enantioselective Degradation and Enantiomerization of Indoxacarb in Soil. Sun, Dali,Liu, Chenglan,Sun, Dali,Pang, Junxiao,Jiao, Bining,Qiu, Jing,Li, Li.

[4]Stereoselective determination of benalaxyl in plasma by chiral high-performance liquid chromatography with diode array detector and application to pharmacokinetic study in rabbits. Wang, Qiuxia,Zhu, Wentao,Jia, Guifang,Wang, Xinquan,Zhou, Zhiqiang.

[5]Subacute oral toxicity assessment of benalaxyl in mice based on metabolomics methods. Wang, Xinru,Wang, Xinru,Wang, Dezhen,Zhou, Zhiqiang,Zhu, Wentao. 2018

[6]The integration of in vivo and in vitro metabolism assays to investigate the stereoselective behaviors of benalaxyl in rainbow trout (Oncorhynchus mykiss). Gu, Xu,Gu, Xu,Yao, Ting. 2013

[7]Enantioselective determination of acylamino acid fungicides in vegetables and fruits by chiral liquid chromatography coupled with tandem mass spectrometry. Zhang, Hu,Wang, Xinquan,Qian, Mingrong,Wang, Xiangyun,Xu, Hao,Qi, Peipei,Wang, Qiang,Zhang, Hu,Wang, Xinquan,Qian, Mingrong,Wang, Xiangyun,Xu, Hao,Qi, Peipei,Wang, Qiang,Zhang, Hu,Wang, Xinquan,Qian, Mingrong,Wang, Xiangyun,Xu, Hao,Qi, Peipei,Wang, Qiang,Zhang, Hu,Wang, Minghua,Zhang, Hu,Wang, Minghua,Jin, Lixia.

[8]Detoxification of diphenyl ether herbicide lactofen by Bacillus sp Za and enantioselective characteristics of an esterase gene lacE. Zhang, Jing,Lu, Luyao,Chen, Feng,Chen, Lingling,Huang, Xing,Zhang, Jing,Yin, Jingang. 2018

[9]Studies of enantiomeric degradation of the triazole fungicide hexaconazole in tomato, cucumber, and field soil by chiral liquid chromatography-tandem mass spectrometry. Dong, Fengshou,Liu, Xingang,Xu, Jun,Chen, Xiu,Han, Yongtao,Liang, Xuyang,Zheng, Yongquan.

[10]Chiral bioaccumulation behavior of tebuconazole in the zebrafish (Danio rerio). Liu, Na,Dong, Fengshou,Xu, Jun,Liu, Xingang,Zheng, Yangquan.

[11]The fate and enantioselective behavior of zoxamide during wine-making process. Dong, Fengshou,Xu, Jun,Liu, Xingang,Wu, Xiaohu,Zheng, Yongquan,Liu, Na,Cheng, Youpu,Chen, Zenglong. 2018

[12]Enantioselective effects of metalaxyl on soil enzyme activity. Yue, Heng,Fang, Song,Zhang, Yizhi,Ning, Yang,Yu, Weisong,Kong, Fanyu,Qiu, Jun,Yue, Heng,Fang, Song,Zhang, Yizhi,Ning, Yang,Yu, Weisong,Kong, Fanyu,Qiu, Jun.

[13]Enantioseparation of Imazalil and Monitoring of Its Enantioselective Degradation in Apples and Soils Using Ultrahigh-Performance Liquid Chromatography Tandem Mass Spectrometry. Li, Runan,Dong, Fengshou,Xu, Jun,Liu, Xingang,Wu, Xiaohu,Pan, Xinglu,Tao, Yan,Chen, Zenglong,Zheng, Yongquan.

[14]Simultaneous enantioselective determination of triazole fungicides in soil and water by chiral liquid chromatography/tandem mass spectrometry. Dong, Fengshou,Liu, Xingang,Xu, Jun,Li, Jing,Kong, Zhiqiang,Chen, Xiu,Liang, Xuyang,Zheng, Yongquan.

[15]Simultaneous enantioselective determination of fenbuconazole and its main metabolites in soil and water by chiral liquid chromatography/tandem mass spectrometry. Dong, Fengshou,Liu, Xingang,Xu, Jun,Li, Jing,Kong, Zhiqiang,Chen, Xiu,Zheng, Yongquan,Song, Wencheng,Wang, Yunhao.

[16]Development of a multi-residue enantiomeric analysis method for 9 pesticides in soil and water by chiral liquid chromatography/tandem mass spectrometry. Dong, Fengshou,Liu, Xingang,Xu, Jun,Chen, Xiu,Han, Yongtao,Liang, Xuyang,Zheng, Yongquan.

[17]Enantioselective separation and transformation of metalaxyl and its major metabolite metalaxyl acid in tomato and cucumber. Dong, Fengshou,Liu, Xingang,Xu, Jun,Chen, Xiu,Han, Yongtao,Cheng, Youpu,Zheng, Yongquan,Jian, Qiu.

[18]Enantioselectivity in tebuconazole and myclobutanil non-target toxicity and degradation in soils. Dong, Fengshou,Liu, Xingang,Xu, Jun,Han, Yongtao,Zheng, Yongquan.

[19]Different Enantioselective Degradation of Pyraclofos in Soils. Zhang, Hu,Qian, Mingrong,Xu, Yuxin,Yu, Man,Xiao, Hua,Zhuang, Shulin.

[20]Enantioselective Degradation of Tebuconazole in Wheat and Soil under Open Field Conditions. Ye, Xiaolan,Peng, Anguo,Peng, Anguo,Qiu, Jing,Chai, Tingting,Zhao, Hualin,Ge, Xinghua. 2013

作者其他论文 更多>>

微信小程序