Intracellular Staphylococcus aureus Control by Virulent Bacteriophages within MAC-T Bovine Mammary Epithelial Cells

文献类型： 外文期刊

第一作者： Zhang, Lili

作者： Zhang, Lili;Sun, Lichang;Wei, Ruicheng;Gao, Qiang;He, Tao;Liu, Xianjin;Wang, Ran;Xu, Cunfa

作者机构：

关键词： MAC-T cells;Staphylococcus aureus;bacteriophages

期刊名称：ANTIMICROBIAL AGENTS AND CHEMOTHERAPY （ 影响因子：5.191； 五年影响因子：5.346 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Bacteriophages (phages) are known to effectively kill extracellular multiplying bacteria. The present study demonstrated that phages penetrated bovine mammary epithelial cells and cleared intracellular Staphylococcus aureus in a timedependent manner. In particular, phage vB_SauM_JS25 reached the nucleus within 3 h postincubation. The phages had an endocytotic efficiency of 12%. This ability to kill intracellular host bacteria suggests the utility of phage-based therapies and may protect patients from recurrent infection and treatment failure.

分类号： R45

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