Structural and evolutionary divergence of aquaporins in parasites

文献类型： 外文期刊

第一作者： Ni, Zi-Xin

作者： Ni, Zi-Xin;Cui, Jian-Min;Zhang, Nian-Zhang;Fu, Bao-Quan;Fu, Bao-Quan

作者机构：

关键词： aquaporin;evolution;genetic variation;drug targets

期刊名称：MOLECULAR MEDICINE REPORTS （ 影响因子：2.952； 五年影响因子：2.754 ）

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年卷期：

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收录情况： SCI

摘要： Aquaporins are ubiquitous proteins that belong to the major intrinsic protein family. Previous studies have indicated that aquaporins are involved in multiple physiological processes in parasites, such as nutrient absorption and end product efflux, and thus, would be promising pharmacological agents in the fight against parasite infection. In the present paper, the authors analyzed the evolutionary relationship of parasitic aquaporins by re-constructing of a phylogenic tree using neighbor-joining and maximum likelihood methods. In addition, the authors discussed the variation of the conserved functional sites impacting on the transportation of water molecules. The protein was concluded to be a potential drug target in parasites.

分类号： R3

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