Structural and evolutionary divergence of aquaporins in parasites

文献类型： 外文期刊

第一作者： Ni, Zi-Xin

作者： Ni, Zi-Xin;Cui, Jian-Min;Zhang, Nian-Zhang;Fu, Bao-Quan;Fu, Bao-Quan

作者机构：

关键词： aquaporin;evolution;genetic variation;drug targets

期刊名称：MOLECULAR MEDICINE REPORTS （ 影响因子：2.952； 五年影响因子：2.754 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Aquaporins are ubiquitous proteins that belong to the major intrinsic protein family. Previous studies have indicated that aquaporins are involved in multiple physiological processes in parasites, such as nutrient absorption and end product efflux, and thus, would be promising pharmacological agents in the fight against parasite infection. In the present paper, the authors analyzed the evolutionary relationship of parasitic aquaporins by re-constructing of a phylogenic tree using neighbor-joining and maximum likelihood methods. In addition, the authors discussed the variation of the conserved functional sites impacting on the transportation of water molecules. The protein was concluded to be a potential drug target in parasites.

分类号： R3

  • 相关文献

[1]Genome-Wide Identification of Jatropha curcas Aquaporin Genes and the Comparative Analysis Provides Insights into the Gene Family Expansion and Evolution in Hevea brasiliensis. Zou, Zhi,Yang, Lifu,Gong, Jun,Mo, Yeyong,Wang, Jikun,Cao, Jianhua,An, Feng,Xie, Guishui. 2016

[2]Comparative proteomic and bioinformatic analysis of Theileria luwenshuni and Theileria uilenbergi. Zhang, Xiao,Li, Youquan,Chen, Ze,Liu, Zhijie,Ren, Qiaoyun,Yang, Jifei,Zhu, Xinquan,Guan, Guiquan,Liu, Aihong,Luo, Jianxun,Yin, Hong,Zhang, Xiao,Li, Youquan,Chen, Ze,Liu, Zhijie,Ren, Qiaoyun,Yang, Jifei,Zhu, Xinquan,Guan, Guiquan,Liu, Aihong,Luo, Jianxun,Yin, Hong,Zhang, Xiao,Li, Youquan,Chen, Ze,Liu, Zhijie,Ren, Qiaoyun,Yang, Jifei,Zhu, Xinquan,Guan, Guiquan,Liu, Aihong,Luo, Jianxun,Yin, Hong.

[3]Genome-wide analysis of excretory/secretory proteins in Echinococcus multilocularis: insights into functional characteristics of the tapeworm secretome. Wang, Shuai,Wei, Wei,Cai, Xuepeng. 2015

[4]Biochemical characterization of enoyl reductase involved in Type II fatty acid synthesis in the intestinal coccidium Eimeria tenella (Phylum Apicomplexa). Cai, Xiaomin,Fuller, A. Lorraine,McDougald, Larry R.,Tan, Xiangshi,Cai, Jianping,Wang, Feng,Sacchettini, James C.,Zhu, Guan.

[5]Expression of Aquaporin BnPIP-like Gene from Rapeseed (Brassica napus) Enhances Salt Resistance in Yeast (Pichia pastoris). Li, Hao-Jie,Zhang, Jin-Fang,Cui, Cheng,Jiang, Jun,Zheng, Ben-Chuan,Jiang, Liang-Cai,Tan, Hao,Zhang, Bi. 2016

[6]Natural variation of salinity response, population structure and candidate genes associated with salinity tolerance in perennial ryegrass accessions. Tang, Jinchi,Yu, Xiaoqing,Camberato, James J.,Jiang, Yiwei,Luo, Na,Xiao, Fangming. 2013

[7]Differential expression of intestinal ion transporters and water channel aquaporins in young piglets challenged with enterotoxigenic Escherichia coli K88. Zhu, C.,Ye, J. L.,Yang, J.,Chen, Z.,Liang, R.,Wu, X. J.,Jiang, Z. Y.,Yang, K. M.,Wang, L.,Jiang, Z. Y.. 2017

[8]Identification of Plasma Membrane Aquaporin in Guard Cells of Vicia faba and Its Role in Stomatal Movement. Huang, RF,Zhu, MJ,Kang, Y,Chen, J,Wang, XC.

[9]Molecular cloning and expression analysis of tea plant aquaporin (AQP) gene family. Yue, Chuan,Cao, Hongli,Wang, Lu,Zhou, Yanhua,Hao, Xinyuan,Zeng, Jianming,Wang, Xinchao,Yang, Yajun,Wang, Lu,Zeng, Jianming,Wang, Xinchao,Yang, Yajun,Yue, Chuan,Cao, Hongli,Wang, Lu,Zhou, Yanhua,Hao, Xinyuan,Zeng, Jianming,Wang, Xinchao,Yang, Yajun.

[10]A Brief Analysis of Subcellular Distribution and Physiological Functions of Plant Aquaporins. Wang Gao-Qi,Chen Jia,Wang Xue-Chen,Pang Yong-Qi,Wang Xu-Chu. 2012

[11]Expression of tomato SlTIP2;2 enhances the tolerance to salt stress in the transgenic Arabidopsis and interacts with target proteins. Xin, Shichao,Yu, Guohong,Qiang, Xiaojing,Xu, Na,Cheng, Xianguo,Sun, Linlin.

[12]TsMIP6 enhances the tolerance of transgenic rice to salt stress and interacts with target proteins. Sun, Linlin,Han, Xiaori,Zhang, Shuhui,Sun, Linlin,Yu, Guohong,Xin, Shichao,Qiang, Xiaojing,Jiang, Linlin,Zhang, Shuhui,Cheng, Xianguo,Xin, Shichao.

[13]Dual regulation of root hydraulic conductivity and plasma membrane aquaporins by plant nitrate accumulation and high-affinity nitrate transporter NRT2.1. Li, Guowei,Tillard, Pascal,Gojon, Alain,Maurel, Christophe,Li, Guowei.

[14]Identification of the AQP members involved in abiotic stress responses from Arabidopsis. Feng, Zhi-Juan,Xu, Sheng-Chun,Liu, Na,Zhang, Gu-Wen,Hu, Qi-Zan,Gong, Ya-Ming,Xu, Zhao-Shi. 2018

[15]Cloning, identification, and bioinformatics analysis of a putative aquaporin TsAQP from Trichinella spiralis. Cui, J. M.,Zhang, N. Z.,Li, W. H.,Yan, H. B.,Fu, B. Q.,Fu, B. Q.. 2015

[16]A banana aquaporin gene, MaPIP1;1, is involved in tolerance to drought and salt stresses. Xu, Yi,Jin, Zhiqiang,Hu, Wei,Liu, Juhua,Zhang, Jianbin,Jia, Caihong,Miao, Hongxia,Xu, Biyu,Jin, Zhiqiang. 2014

[17]Expression, Distribution and Role of Aquaporin Water Channels in Human and Animal Stomach and Intestines. Zhu, Cui,Chen, Zhuang,Jiang, Zongyong,Jiang, Zongyong. 2016

[18]An aquaporin protein is associated with drought stress tolerance. Li, Jun,Wen, Hongyu,Wang, Zan,Gao, Hongwen,Wang, Xuemin,Li, Jun,Ban, Liping,Dzyubenko, Nikolay,Chapurin, Vladimir.

[19]Roles of Plasmalemma Aquaporin Gene StPIP1 in Enhancing Drought Tolerance in Potato. Wang, Li,Liu, Yuhui,Yang, Jiangwei,Zhang, Junlian,Wang, Li,Yang, Jiangwei,Feng, Shoujiang,Li, Dan,Zhang, Junlian. 2017

[20]Genome-wide identification of rubber tree (Hevea brasiliensis Muell. Arg.) aquaporin genes and their response to ethephon stimulation in the laticifer, a rubber-producing tissue. Zou, Zhi,Gong, Jun,An, Feng,Xie, Guishui,Wang, Jikun,Mo, Yeyong,Yang, Lifu. 2015

作者其他论文 更多>>
  • AP2X-8 Is Important for Tachyzoite Growth and Bradyzoite Differentiation of Toxoplasma gondii

    作者：Sun, Li-Xiu;Liu, Guo-Hua;Sun, Li-Xiu;Wang, Meng;Xie, Shi-Chen;Fu, Bao-Quan;Elsheikha, Hany M.;Zhu, Xing-Quan

    关键词：Toxoplasma gondii; toxoplasmosis; AP2 transcription factors; AP2X-8; tachyzoite growth; bradyzoite differentiation

  • Spatiotemporal Transcriptomic Profiling Reveals the Dynamic Immunological Landscape of Alveolar Echinococcosis

    作者：Ou, Zhihua;Ren, Peidi;He, Fan;Chen, Jialing;Tan, Qiming;Chen, Qi;Zhang, Qian;Ou, Zhihua;Ren, Peidi;He, Fan;Chen, Jialing;Cai, Huimin;Li, Jiandong;Tan, Qiming;Chen, Qi;He, Xiuju;Zhao, Yanping;Zhang, Qian;Liang, Yingan;Li, Junhua;Li, Li;Zhou, Ting-Ting;Wu, Yao-Dong;Li, Xiu-Rong;Li, Wenhui;Zhang, Nian-Zhang;Chen, Wei-Gang;Sun, Jiwen;Wu, Yan-Tao;You, Jie;Tian, Xue-Qi;Fu, Bao-Quan;Cai, Xue-Peng;Jia, Wan-Zhong;Yan, Hong-Bin;Li, Li;Zhou, Ting-Ting;Wu, Yao-Dong;Li, Xiu-Rong;Li, Wenhui;Zhang, Nian-Zhang;Chen, Wei-Gang;Sun, Jiwen;Wu, Yan-Tao;You, Jie;Tian, Xue-Qi;Fu, Bao-Quan;Cai, Xue-Peng;Jia, Wan-Zhong;Yan, Hong-Bin;He, Fan;Chen, Jialing;Chen, Qi;Zhang, Qian;Cai, Huimin;Li, Jiandong;He, Xiuju;Zhao, Yanping;Liao, Sha;Yang, Huanming;Wang, Jian;Jin, Xin;Xu, Xun;Han, Xiumin;Tan, Qiming;Liang, Yingan;Hu, Guohai;Wang, Jian;Chen, Ao;Chen, Ao;Jin, Xin;Jin, Xin;Xu, Xun;Li, Junhua

    关键词：Echinococcus multilocularis; macrophages; neutrophils; single-cell RNA sequencing; spatial transcriptomics

  • Epidemiology, molecular diversity and zoonotic implications of Echinococcus granulosus sensu stricto (G1) in cattle across Nigeria: Evidence of broader transmission dynamics

    作者：Amuda, Tharheer Oluwashola;Li, Li;Wang, Li-Qun;Dai, Guo-Dong;Chen, Wei-Gang;Wu, Yao-Dong;Wu, Ke-Ke;Wu, Yixuan;Yin, Hong;Jia, Wan-Zhong;Fu, Bao-Quan;Luo, Xue-Nong;Yan, Hong-Bin;Amuda, Tharheer Oluwashola;Li, Li;Wang, Li-Qun;Dai, Guo-Dong;Chen, Wei-Gang;Wu, Yao-Dong;Wu, Ke-Ke;Wu, Yixuan;Yin, Hong;Jia, Wan-Zhong;Fu, Bao-Quan;Luo, Xue-Nong;Yan, Hong-Bin;Morenikeji, Olajumoke Abimbola;Odaibo, Georgina Nijideka;Onoja, Bernard Anyebe;Akanbi, Ibikunle Mark;Yin, Hong;Jia, Wan-Zhong;Fu, Bao-Quan;Luo, Xue-Nong

    关键词：Echinococcus granulosus sensu lato; Cystic echinococcosis; Nigeria; Genetic diversity; Molecular epidemiology; One health

  • AP2XII-9 is essential for parasite growth and suppresses bradyzoite differentiation in Toxoplasma gondii

    作者：Wu, Xiao-Jing;Wang, Meng;Zhang, Nian-Zhang;Li, Ting-Ting;Gao, Jin;Sun, Li-Xiu;Wang, Jin-Lei;Wu, Xiao-Jing;Gao, Jin;Zhu, Xing-Quan

    关键词：AP2XII-9; apicoplast inheritance; asynchronous division; bradyzoite differentiation; growth; membrane defect; Toxoplasma gondii

  • A new intermediate host of Echinococcus shiquicus in Qinghai-Tibet Plateau, China

    作者：Chen, Wei-Gang;Li, Li;Dai, Guo-Dong;Wu, Yao-Dong;Amuda, Tharheer Oluwashola;Tian, Xue-Qi;Zhang, Nian-Zhang;Tian, Wen-Jun;Zhang, Lin-Sheng;Li, Le;Fu, Bao-Quan;Yin, Hong;Yan, Hong-Bin;Jia, Wan-Zhong;Chen, Wei-Gang;Li, Li;Dai, Guo-Dong;Wu, Yao-Dong;Amuda, Tharheer Oluwashola;Tian, Xue-Qi;Hou, Xue-Yi;Zhang, Nian-Zhang;Tian, Wen-Jun;Zhang, Lin-Sheng;Li, Le;Fu, Bao-Quan;Yin, Hong;Yan, Hong-Bin;Jia, Wan-Zhong;Chen, Wei-Gang;Li, Li;Dai, Guo-Dong;Wu, Yao-Dong;Amuda, Tharheer Oluwashola;Tian, Xue-Qi;Zhang, Nian-Zhang;Tian, Wen-Jun;Zhang, Lin-Sheng;Li, Le;Fu, Bao-Quan;Yin, Hong;Yan, Hong-Bin;Jia, Wan-Zhong;Chen, Wei-Gang;Li, Li;Dai, Guo-Dong;Wu, Yao-Dong;Amuda, Tharheer Oluwashola;Tian, Xue-Qi;Zhang, Nian-Zhang;Tian, Wen-Jun;Zhang, Lin-Sheng;Li, Le;Fu, Bao-Quan;Yin, Hong;Yan, Hong-Bin;Jia, Wan-Zhong;Chen, Wei-Gang;Li, Li;Dai, Guo-Dong;Wu, Yao-Dong;Amuda, Tharheer Oluwashola;Tian, Xue-Qi;Zhang, Nian-Zhang;Tian, Wen-Jun;Zhang, Lin-Sheng;Li, Le;Guo, Min-Kuan;Li, Wen-Dong;Fu, Bao-Quan;Yin, Hong;Yan, Hong-Bin;Jia, Wan-Zhong;Chen, Wei-Gang;Li, Li;Dai, Guo-Dong;Wu, Yao-Dong;Amuda, Tharheer Oluwashola;Tian, Xue-Qi;Zhang, Nian-Zhang;Tian, Wen-Jun;Zhang, Lin-Sheng;Li, Le;Li, Wen-Dong;Fu, Bao-Quan;Yin, Hong;Yan, Hong-Bin;Jia, Wan-Zhong;Chen, Wei-Gang;Li, Li;Dai, Guo-Dong;Wu, Yao-Dong;Amuda, Tharheer Oluwashola;Tian, Xue-Qi;Zhang, Nian-Zhang;Tian, Wen-Jun;Zhang, Lin-Sheng;Li, Le;Fu, Bao-Quan;Yin, Hong;Yan, Hong-Bin;Jia, Wan-Zhong;Shumuye, Nigus Abebe;Gao, Sheng-Zhi;Hou, Xue-Yi;Zhonggecao, Tao;Zhaxilamao, Bao-Quan;Gazangzhuoma, Hong;Doukao, Hong-Bin;Zhang, Fu-Heng;Guo, Min-Kuan;Li, Wen-Dong;Yang, Tao;Fu, Bao-Quan;Yin, Hong;Jia, Wan-Zhong

    关键词：Echinococcus shiquicus; Plateau zokor; Intermediate host; Qinghai-Tibet Plateau; Genetic diversity

  • AP2X-1 is a negative regulator of Toxoplasma gondii sexual commitment

    作者：Sun, Li-Xiu;Wang, Meng;Zhang, Tian-Yu;Zhang, Zhi-Wei;Fu, Bao-Quan;Wang, Jin-Lei;Sun, Li-Xiu;Zhang, Tian-Yu;Liu, Guo-Hua;Elsheikha, Hany M.;Zheng, Xiao-Nan;Zhu, Xing-Quan

    关键词：Toxoplasma gondii; AP2X-1; HDAC3/MORC complex; gene expression; sexual development; transcription

  • The PP2A-2 holoenzyme orchestrates daughter cell emergence during cytokinesis in Toxoplasma gondii

    作者：Wang, Jin-Lei;Wang, Meng;Zhang, Nian-Zhang;Li, Ting-Ting;Gao, Jin;Wu, Xiao-Jing;Fu, Bao-Quan;Wang, Jin-Lei;Wang, Meng;Zhang, Nian-Zhang;Li, Ting-Ting;Gao, Jin;Wu, Xiao-Jing;Fu, Bao-Quan;Gao, Jin;Wu, Xiao-Jing;Zhu, Xing-Quan;Elsheikha, Hany M.

    关键词：

微信小程序