The single and joint toxicity effects of chlorpyrifos and beta-cypermethrin in zebrafish (Danio rerio) early life stages

文献类型： 外文期刊

第一作者： Zhang, Jiayu

作者： Zhang, Jiayu;Liu, Lili;Ren, Lei;Feng, Weimin;Lv, Peng;Wu, Wei;Yan, Yanchun

作者机构：

关键词： Pesticides;Zebrafish embryo;Developmental toxicity;Oxidative stress;RNA-Seq

期刊名称：JOURNAL OF HAZARDOUS MATERIALS （ 影响因子：10.588； 五年影响因子：10.129 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Water environment pollution caused by the widespread application of beta-cypermethrin (BCP) and chlorpyrifos (CPF) in agriculture has attracted extensive concern of the world. In this study, zebrafish was used as a model to investigate the individual and joint toxicity of BCP and CPF. In the acute toxicity test, 3 hpf embryos were exposed to various concentrations of CPF, BCP and their binary mixtures (MIX) for 96 h. The results indicated that these two pesticides and mixtures induced malformation and death in larvae, and affected hatchability. These two pesticides in mixtures were verified to act together in a synergistic manner under experimental conditions. Oxidative stress assaying manifested that CPF, BCP and MIX altered CAT, SOD and GST activities and MDA content, resulting in oxidative damage in larvae. By pathology analysis, CPF (236 mu g/L), BCP (5.9 mu g/L) and MIX (236 mu g/L CPF + 5.9 mu g/L BCP) were found to trigger liver lesions and promote apoptosis in tissues. The transcriptome sequencing suggested that ECM-receptor interaction, focal adhesion, cell cycle, DNA replication, phototransduction and adherens junction pathways were closely associated with the toxicity of these two pesticides. (C) 2017 Elsevier B.V. All rights reserved.

分类号： TB1

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