The 1910HK/RR two-component system is essential for the virulence of Streptococcus suis serotype 2

文献类型: 外文期刊

第一作者: Yuan, Fangyan

作者: Yuan, Fangyan;Tan, Chen;Chen, Huanchun;Bei, Weicheng;Yuan, Fangyan;Liu, Zewen;Yang, Keli;Zhou, Danna;Liu, Wei;Duan, Zhengying;Guo, Rui;Tian, Yongxiang;Tan, Chen;Chen, Huanchun;Bei, Weicheng

作者机构:

关键词: Streptococcus suis;1910HK/RR;Two-component system;Virulence

期刊名称:MICROBIAL PATHOGENESIS ( 影响因子:3.738; 五年影响因子:3.663 )

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收录情况: SCI

摘要: Streptococcus suis serotype 2 is a major zoonotic pathogen, and the two-component system plays an important role in bacterial pathogenesis. The present study targeted the 1910HK/RR two-component system of S. suis 2. A 19101-1K/RR deletion mutant (Delta 1910HK/RR) and the corresponding complementation strain (C Delta 1910HK/RR) were constructed in S. suis 2 strain 05ZYH33. 1910HK/RR deletion had no effect on S. suis 2 growth, but significantly inhibited the adherence and invasion of S. suis 2 to HEp-2 cells. Analysis of the role of 1910HK/12R in murine and pig infection models demonstrated that 1910HK/RR played a distinct role in the virulence of S. suis 2. In addition, deletion of 1910HK/RR significantly impaired the survival of 05ZYH33 in human blood. These data provided important insights into the pathogenesis of S. suis 2. (C) 2017 Elsevier Ltd. All rights reserved.

分类号: R3

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