Chrodrimanins K-N and Related Meroterpenoids from the Fungus Penicillium sp. SCS-KFD09 Isolated from a Marine Worm, Sipunculus nudus

文献类型： 外文期刊

第一作者： Kong, Fan-Dong

作者： Kong, Fan-Dong;Ma, Qing-Yun;Huang, Sheng-Zhuo;Wang, Pei;Zhou, Li-Man;Yuan, Jing-Zhe;Dai, Hao-Fu;Zhao, You-Xing;Wang, Jun-Feng

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期刊名称：JOURNAL OF NATURAL PRODUCTS （ 影响因子：4.05； 五年影响因子：4.603 ）

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收录情况： SCI

摘要： Six new meroterpenoids, chrodrimanins K-N (1-4), including two uncommon chlorinated one (1 and 2), and verruculides B2 (5) and B3 (6), as well as seven known ones (7-13), were isolated from the fermentation broth of Penitillinm sp. SCS-KFD09, isolated from a marine worm, Sipunculus nuchis, from Haikou Bay, China., The, structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data, X-ray diffraction analysis, and ECD spectra analysis along with quantum ECD calculations. In addition, the X-ray crystal structures and, absolute configurations :of two previously reported tneroterpenoids, chrodrimanins F (9) and A (11), are described for the first time. Compounds 1, 4, and 7 displayed anti-H1N1 activity with IC50 values of-74,, 58, and 34 mu M, respectively, while compound 5 showed, weak inhibitory activity against Staphylococcus atireas with an MIC of 32 mu g/mL.

分类号： R93

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