Recombinant Newcastle disease virus expressing human TRAIL as a potential candidate for hepatoma therapy

文献类型: 外文期刊

第一作者: Wu, Yunzhou

作者: Wu, Yunzhou;An, Ying;Yan, Shijun;Yin, Jiechao;Li, Deshan;He, Jinjiao;Geng, Jingshu;Ye, Xianlong;Yu, Qingzhong;Zhang, Zhenyu

作者机构:

关键词: Newcastle disease virus;Oncolysis;Hepatoma;Hepatocellular carcinoma;TRAIL

期刊名称:EUROPEAN JOURNAL OF PHARMACOLOGY ( 影响因子:4.432; 五年影响因子:4.014 )

ISSN:

年卷期:

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收录情况: SCI

摘要: Newcastle disease-virus (NDV) have shown oncolytic therapeutic efficacy in preclinical studies and are currently proved for clinical trials. We have previously reported, for the first time, NDV Anhinga strain has an efficient cancer therapeutic efficacy in hepatoma. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) functions as a cytokine to selectively kill various cancer cells without toxicity to most normal cells. Numerous studies have demonstrated the potential use of recombinant soluble TRAIL as a cancer therapeutic agent. In this study, we have showed administration of a recombinant NDV Anhinga strain expressing soluble TRAIL (NDV/Anh-TRAIL) results in an efficient suppression of hepatocellular carcinoma without significant toxicity. The results show that recombinant NDV Anhinga strain expressing soluble TRAIL is a promising candidate for hepatoma therapy.

分类号: R96

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