A pilot study on interaction between donkey tetherin and EIAV stains with different virulent and replication characteristics

文献类型： 外文期刊

第一作者： Yao, Qiucheng

作者： Yao, Qiucheng;Li, Yanfei;Yao, Qiucheng;Ma, Jian;Wang, Xuefeng;Guo, Miaomiao;Wang, Xiaojun

作者机构：

关键词： Tetherin;EIAV;Interaction;Evolution

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

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收录情况： SCI

摘要： Tetherin (BST-2) is an important host restriction factor that can inhibit the release of a diverse array of enveloped viruses from infected cells. Conversely, to facilitate their release and spread, many viruses have evolved various strategies to overcome the antiviral effect of tetherin in a species-specific manner. During the development of an attenuated equine infectious anemia virus (EIAV) vaccine in our laboratory, we found that serial passage of a field-isolated virulent EIAV strains in horse and donkey as well as the cultivated donkey cells, produces several typical EIAV strains, including EIAV(DV), EIAV(DLV), and EIAV(FDDV), which exhibit distinct virulence and replication features in vivo and in vitro. However, the role of host restriction factors in EIAV evolution during the serial passage is not well understood. This study aimed to evaluate whether these newly generated strains adapt differently to donkey tetherin (dotetherin) based on their virulence. We found that do-tetherin exerts an inhibition on the release of the viral particles produced by all three strains, albeit with varying intensity: EIAV(DV) < EIAV(DLV) < EIAV(FDDV). Additionally, all three EIAV strains could counteract the restriction mediated by do-tetherin via their envelope proteins (Env) with varying strength: EIAV(DV) > EIAV(DLV) > EIAV(FDDV). These results indicate that donkey tetherin is involved in shaping of EIAV evolution during serial passage. (C) 2016 Elsevier Ltd. All rights reserved.

分类号： R3

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