Rapid acquisition adaptive amino acid substitutions involved in the virulence enhancement of an H1N2 avian influenza virus in mice
文献类型: 外文期刊
第一作者: Yu, Zhijun
作者: Yu, Zhijun;Sun, Weiyang;Zhang, Xinghai;Xia, Xianzhu;Gao, Yuwei;Xia, Xianzhu;Gao, Yuwei;Cheng, Kaihui;Zhao, Chuqi
作者机构:
关键词: Avian influenza virus;H1N2;Wild waterfowl;Adaptation;Mice
期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Although H1N2 avian influenza virus (AIV) only infect birds, documented cases of swine infection with H1N2 influenza viruses suggest this subtype AIV may pose a potential threat to mammals. Here, we generated mouse-adapted variants of a H1N2 MV to identify adaptive changes that increased virulence in mammals. MLD50 of the variants were reduced > 1000-fold compared to the parental virus. Variants displayed enhanced replication in vitro and in vivo, and replicate in extrapulmonary organs. These data show that enhanced replication capacity and expanded tissue tropism may increase the virulence of H1N2 AIV in mice. Sequence analysis revealed multiple amino acid substitutions in the PB2 (L134H, I647L, and D701N), HA (G228S), and M1 (D231N) proteins. These results indicate that H1N2 AIV can rapidly acquire adaptive amino acid substitutions in mammalian hosts, and these amino acid substitutions collaboratively enhance the ability of H1N2 AIV to replicate and cause severe disease in mammals.
分类号: S8
- 相关文献
作者其他论文 更多>>
-
An inactivated influenza D virus vaccine protects guinea pigs from infections and contact transmission caused by homologous challenge
作者:Dong, Zhipeng;Gao, Hongbo;Wang, Tiecheng;Xia, Xianzhu;Sun, Weiyang;Gao, Yuwei;Dong, Zhipeng;Lu, Pengyang;Wang, Tiecheng;Xia, Xianzhu;Feng, Yue;Wan, Wentao
关键词:Influenza D virus; Inactivated vaccine; Contact transmission; Guinea pigs
-
Targeting SARM1 as a novel neuroprotective therapy in neurotropic viral infections
作者:He, Sheng;Zhu, Yanyan;Wang, Xinyue;Zhang, Gaofeng;Xia, Xianzhu;Zhao, Pingsen;He, Sheng;Zhu, Yanyan;Wang, Xinyue;Zhang, Gaofeng;Xia, Xianzhu;Zhao, Pingsen;He, Sheng;Zhu, Yanyan;Wang, Xinyue;Zhang, Gaofeng;Xia, Xianzhu;Zhao, Pingsen;He, Sheng;Zhu, Yanyan;Wang, Xinyue;Zhang, Gaofeng;Zhao, Pingsen;He, Sheng;Zhu, Yanyan;Wang, Xinyue;Zhang, Gaofeng;Zhao, Pingsen;He, Sheng;Zhu, Yanyan;Wang, Xinyue;Zhang, Gaofeng;Zhao, Pingsen;He, Sheng;Gong, Xiaoqian;Zhao, Pingsen;Hou, Kaijian;Xia, Xianzhu;Jiang, Zhenyou
关键词:Viral encephalitis; Neurotropic virus; SARM1; Axonal degeneration; Neuropathology; Brain inflammation
-
Discovery of TRPV4-Targeting Small Molecules with Anti-Influenza Effects Through Machine Learning and Experimental Validation
作者:Sun, Yan;Yan, Fang;Sun, Yan;Wu, Jiajing;Shen, Beilei;Luo, Rongbo;Zhang, Shijun;Li, He;Qian, Bingshuo;Fan, Lingjun;Zhang, Junkui;Wang, Tiecheng;Xia, Xianzhu;Gao, Yuwei;Yang, Hengzheng;Cui, Huizi;Han, Weiwei;Xia, Xianzhu
关键词:TRPV4; anti-influenza; machine learning; repurposing drugs; molecular docking
-
Taurolidine inhibits influenza virus infection and prevents influenza-induced cytokine storm, vasoconstriction and lung damage
作者:Lv, Chaoxiang;Lv, Chaoxiang;Guo, Jin;Luo, Rongbo;Li, Yuanguo;Qian, Bingshuo;Wang, Tiecheng;Shen, Beilei;Sun, Weiyang;Gao, Yuwei;Lv, Chaoxiang;Guo, Jin;Gao, Yuwei;Qian, Bingshuo;Zou, Xiaopan;Gao, Yuwei
关键词:Taurolidine; Vasoconstriction; Influenza virus; Calcium influx; MLCK/p-MLC signaling pathway
-
Progress in combination vaccines and the co-administration of influenza virus and SARS-CoV-2 vaccines
作者:Hu, Chengyu;Niu, Chenguang;Li, Xiaohui;Wei, Qiannan;Ren, Zhiguang;Li, Xiaodong;He, Ke;Li, Mengyu;Gao, Xiaonan;Ren, Zhiguang;Sun, Weiyang;Zhao, Yongkun;Li, Yuanguo;Xia, Xianzhu;Ren, Zhiguang;Wang, Tiecheng;Xia, Xianzhu;Wang, Tiecheng
关键词:SARS-CoV-2; influenza virus; coinfection; coadministration; combination vaccines
-
EIDD-2801 resists to infection and co-infection of SARS-CoV-2 and influenza virus
作者:Qian, Bingshuo;Luo, Rongbo;Shen, Beilei;Fan, Lingjun;Zhang, Junkui;Zhang, Shijun;Sun, Yan;Deng, Xiuwen;Gao, Yuwei;Qian, Bingshuo;Zhang, Junkui;Pang, Xiaobin;Zhong, Wu
关键词:Antiviral activity; Respiratory viruses; Influenza; SARS-CoV-2; EIDD-2801; Co-infection.
-
Exploring the pathogenic and transmission characteristics of JN.1 in golden hamsters based on different attack methods
作者:Liu, Ruixue;Song, Fang;Sun, Li;Yan, Fang;Yan, Fang;Gao, Yuwei;Liu, Ruixue;Song, Fang;Sun, Li;Yan, Fang;Jin, Qiushi;Yan, Fang;Xia, Xianzhu;Wang, Xuefeng;Gao, Yuwei
关键词:SARS-CoV-2; Attack methods; JN.1; Pathogenicity; Transmission