Rapid acquisition adaptive amino acid substitutions involved in the virulence enhancement of an H1N2 avian influenza virus in mice

文献类型: 外文期刊

第一作者: Yu, Zhijun

作者: Yu, Zhijun;Sun, Weiyang;Zhang, Xinghai;Xia, Xianzhu;Gao, Yuwei;Xia, Xianzhu;Gao, Yuwei;Cheng, Kaihui;Zhao, Chuqi

作者机构:

关键词: Avian influenza virus;H1N2;Wild waterfowl;Adaptation;Mice

期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )

ISSN:

年卷期:

页码:

收录情况: SCI

摘要: Although H1N2 avian influenza virus (AIV) only infect birds, documented cases of swine infection with H1N2 influenza viruses suggest this subtype AIV may pose a potential threat to mammals. Here, we generated mouse-adapted variants of a H1N2 MV to identify adaptive changes that increased virulence in mammals. MLD50 of the variants were reduced > 1000-fold compared to the parental virus. Variants displayed enhanced replication in vitro and in vivo, and replicate in extrapulmonary organs. These data show that enhanced replication capacity and expanded tissue tropism may increase the virulence of H1N2 AIV in mice. Sequence analysis revealed multiple amino acid substitutions in the PB2 (L134H, I647L, and D701N), HA (G228S), and M1 (D231N) proteins. These results indicate that H1N2 AIV can rapidly acquire adaptive amino acid substitutions in mammalian hosts, and these amino acid substitutions collaboratively enhance the ability of H1N2 AIV to replicate and cause severe disease in mammals.

分类号: S8

  • 相关文献

[1]Multiple adaptive amino acid substitutions increase the virulence of a wild waterfowl-origin reassortant H5N8 avian influenza virus in mice. Yu, Zhijun,Sun, Weiyang,Zhang, Xinghai,Xia, Xianzhu,Gao, Yuwei,Xia, Xianzhu,Gao, Yuwei,Cheng, Kaihui,Xia, Xianzhu,Gao, Yuwei. 2018

[2]Multiple amino acid substitutions involved in the adaptation of H6N1 avian influenza virus in mice. Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Cheng, Kaihui,Xin, Yue,Sun, Weiyang,Li, Xue,Huang, Jing,Zhang, Kun,Yang, Songtao,Wang, Tiecheng,Zheng, Xuexing,Wang, Hualei,Qin, Chuan,Xia, Xianzhu,Cheng, Kaihui,Chai, Hongliang.

[3]PB2-E627K and PA-T97I substitutions enhance polymerase activity and confer a virulent phenotype to an H6N1 avian influenza virus in mice. Cheng, Kaihui,Yu, Zhijun,Sun, Weiyang,Xin, Yue,Huang, Jing,Zhang, Kun,Li, Xue,Yang, Songtao,Wang, Tiecheng,Zheng, Xuexing,Wang, Hualei,Qian, Jun,Gao, Yuwei,Xia, Xianzhu,Cheng, Kaihui,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Qin, Chuan,Xia, Xianzhu,Zhang, Qianyi,Chen, Hualan,Chai, Hongliang,Hua, Yuping.

[4]Novel triple reassortant H1N2 influenza viruses bearing six internal genes of the pandemic 2009/H1N1 influenza virus were detected in pigs in China. Qiao, Chuanling,Liu, Liping,Yang, Huanliang,Chen, Yan,Xu, Huiyang,Chen, Hualan.

[5]Pathogenic characteristics of a novel triple-reasserted H1N2 swine influenza virus. Liu, Huili,Tao, Jie,Zhang, Pengchao,Yin, Xiuchen,Ha, Zhuo,Zhang, Chunling,Liu, Huili,Tao, Jie,Yin, Xiuchen.

[6]Two different genotypes of H1N2 swine influenza virus isolated in northern China and their pathogenicity in animals. Yang, Huanliang,Chen, Yan,Qiao, Chuanling,Xin, Xiaoguang,Bu, Zhigao,Chen, Hualan,Xu, Chuantian,Yan, Minghua.

[7]Two genotypes of H1N2 swine influenza viruses appeared among pigs in China. Xu, Chuantian,Zhu, Qiyun,Yang, Huanliang,Qiao, Chuanling,Chen, Yan,Xin, Xiaoguang,Chen, Hualan,Xu, Chuantian,Zhu, Qiyun,Yang, Huanliang,Qiao, Chuanling,Chen, Yan,Xin, Xiaoguang,Chen, Hualan,Xu, Chuantian,Zhang, Xiumei. 2009

[8]Molecular characterization of a novel reassortant H1N2 influenza virus containing genes from the 2009 pandemic human H1N1 virus in swine from eastern China. Peng, Xiuming,Wu, Haibo,Peng, Xiaorong,Cheng, Linfang,Jin, Changzhong,Xie, Tiansheng,Lu, Xiangyun,Wu, Nanping,Xu, Lihua.

[9]Sequence analysis of the haemagglutinin genes of H9N2 avian influenza viruses isolated in China during 1996 to 2011. Dai, Yin,Zhao, Ruihong,Hu, Xiaomiao,Zhang, Danjun,Wang, Junjun,Xu, Fazhi. 2012

[10]Diversified reassortant H9N2 avian influenza viruses in chicken flocks in northern and eastern China. Huang, Yanyan,Hu, Beixia,Zhang, Xiumei,Huang, Yanyan,Wen, Xintian,Cao, Sanjie,Du, Qijing,Gavrilov, Boris K.,Khan, Mazhar I.. 2010

[11]New H6 influenza virus reassortment strains isolated from Anser fabalis in Anhui Province, China. Ge, Ye,Yao, Qiucheng,Ma, Jian,Chen, Si,Deng, Guohua,Chen, Hualan,Ge, Ye,Chai, Hongliang,Hua, Yuping,Fan, Zhiqiang,Wang, Xianfu. 2017

[12]Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice. Bi, Yuhai,Lu, Lu,Li, Jing,Zeshan, Basit,Sun, Lei,Liu, Wenjun,Lu, Lu,Yin, Yanbo,Qin, Zhuoming,Zhang, Yi,Gao, Huijie,Liu, Jinhua. 2011

[13]Sequence and phylogenetic analysis of hemagglutinin genes of H9N2 influenza viruses isolated from chicken in China from 2013 to 2015. Su Xiao-na,Xie Qing-mei,Chen Wei-guo,Bi Ying-zuo,Chen Feng,Su Xiao-na,Xie Qing-mei,Chen Feng,Su Xiao-na,Xie Qing-mei,Chen Feng,Liao Chang-tao,Yan Zhuan-qiang. 2016

[14]The first lack of evidence of H7N9 avian influenza virus infections among pigs in Eastern China. Zhao, Fu-Rong,Zhou, Dong-Hui,Lin, Tong,Shao, Jun-Jun,Wei, Ping,Zhang, Yong-Guang,Chang, Hui-Yun,Wei, Ping.

[15]New influenza A(H7N7) viruses detected in live poultry markets in China. Cui, Pengfei,Chen, Hualan,Cui, Pengfei,Deng, Guohua,Shi, Jianzhong,Kong, Huihui,Liu, Liling,Guan, Yuntao,Chen, Hualan,Suzuki, Yasuo.

[16]Detection and differentiation of four poultry diseases using asymmetric reverse transcription polymerase chain reaction in combination with oligonucleotide microarrays. Tao, Qimeng,Wang, Xiurong,Bao, Hongmei,Wu, Jianan,Shi, Lin,Li, Yanbing,Qiao, Chuanling,Chen, Hualan,Tao, Qimeng,Wang, Xiurong,Bao, Hongmei,Wu, Jianan,Shi, Lin,Li, Yanbing,Qiao, Chuanling,Chen, Hualan,Yakovlevich, Samuilenko Anatolij,Mikhaylovna, Poukhova Nina.

[17]Efficacy of a high-yield attenuated vaccine strain wholly derived from avian influenza viruses by use of reverse genetics. Liu, Ming,Liu, Ming.

[18]Non-thermal plasma for inactivated-vaccine preparation. Wang, Guomin,Wang, Kaile,Zhang, Qian,Zhang, Jue,Fang, Jing,Zhu, Ruihao,Yang, Licong,Su, Xia,Yang, Bing,Zhang, Jue,Fang, Jing.

[19]Lowly pathogenic avian influenza (H9N2) infection in Plateau pika (Ochotona curzoniae), Qinghai Lake, China. Yu, Zhijun,Zhang, Kun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Zhang, Kun,Qin, Chuan,Xia, Xianzhu,Yu, Zhijun,Cheng, Kaihui,Sun, Weiyang,Xin, Yue,Li, Lin,Huang, Jing,Sang, Xiaoyu,Li, Xue,Wang, Tiecheng,Qian, Jun,Gao, Yuwei,Xia, Xianzhu,Cai, Jinshan,Ma, Ruilin,Zhao, Quanbang,Cheng, Kaihui,Huang, Jing,Li, Xue.

[20]Pathogenesis and Phylogenetic Analyses of Two Avian Influenza H7N1 Viruses Isolated from Wild Birds. Jin, Hongmei,Sun, Jing,Chen, Guang,Zhang, Xiaolin,Zhang, Jiajie,Li, Xiang,Chai, Hongliang,Hua, Yuping,Wang, Deli,Cui, Yanfang,Li, Yanbing,Sun, Jing,Chen, Guang,Gao, Yuwei. 2016

作者其他论文 更多>>