Newcastle disease virus-like particles induce DC maturation through TLR4/NF-kappa B pathway and facilitate DC migration by CCR7-CCL19/CCL21 axis

文献类型： 外文期刊

第一作者： Qian, Jing

作者： Qian, Jing;Xu, Xiaohong;Ding, Jiaxin;Yin, Renfu;Xue, Cong;Cong, Yanlong;Ding, Zhuang;Sun, Yixue;Wang, Jianzhong;Wang, Chunfeng;Ding, Chan;Yu, Shengqing;Liu, Xiufan;Hu, Shunlin

作者机构：

关键词： Newcastle disease virus-like particles;Dendritic cells;Maturation;Migration;Innate immunity

期刊名称：VETERINARY MICROBIOLOGY （ 影响因子：3.293； 五年影响因子：3.599 ）

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收录情况： SCI

摘要： Newcastle disease virus-like particles (NDV VLPs) are a potential candidate vaccine, as shown by eliciting specific immune response against NDV in mice and chickens. Activation of dendritic cells (DCs) is critical to initiate immune response. However, the mechanism of how NDV VLPs induce DC maturation and migration remains elusive. In this study, we found that NDV VLPs are efficient in DC activation by up regulating surface MHC II and costimulatory molecules, and proinflammatory cytokines through the TLR4/NF-kappa B pathway. Furthermore, NDV VLP5 elevated CCR7 expression on DCs, resulting in DC migration towards CCL19/CCL21 both in vitro and ex vivo. As a consequence of DC maturation and migration, CD4+ T cells were also activated in vivo, demonstrating increased intracellular IFN-gamma and IL-4 levels. Together, these results present new insights for NDV VLPs induced DC maturation and migration, providing a better understanding of VLP-triggered innate immune responses. (C) 2017 Elsevier B.V. All rights reserved.

分类号： Q2

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