PA-X protein decreases replication and pathogenicity of swine influenza virus in cultured cells and mouse models
文献类型: 外文期刊
第一作者: Gong, Xiao-Qian
作者: Gong, Xiao-Qian;Ruan, Bao-Yang;Liu, Xiao-Min;Wang, Qi;Yang, Hai-Ming;Wang, Shuai-Yong;Zhang, Peng;Wang, Xiu-Hui;Shan, Tong-Ling;Tong, Wu;Zhou, Yan-Jun;Li, Guo-Xin;Zheng, Hao;Tong, Guang-Zhi;Yu, Hai;Sun, Ying-Feng;Shan, Tong-Ling;Tong, Wu;Zhou, Yan-Jun;Li, Guo-Xin;Zheng, Hao;Tong, Guang-Zhi;Yu, Hai
作者机构:
关键词: Swine influenza virus;Pa-x;Pathogenicity;Virus replication;Polymerase activity
期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )
ISSN:
年卷期:
页码:
收录情况: SCI
摘要: Swine influenza viruses have been circulating in pigs throughout world and might be potential threats to human health. PA-X protein is a newly discovered protein produced from the PA gene by ribosomal frameshifting and the effects of PA-X on the 1918 H1N1, the pandemic 2009 H1N1, the highly pathogenic avian H5N1 and the avian H9N2 influenza viruses have been reported. However, the role of PA-X in the pathogenesis of swine influenza virus is still unknown. In this study, we rescued the H1N1 wild-type (WT) classical swine influenza virus (A/Swine/Guangdong/1/2011 (H1N1)) and H1N1 PA-X deficient virus containing mutations at the frameshift motif, and compared their replication properties and pathogenicity of swine influenza virus in vitro and in vivo. Our results show that the expression of PA-X inhibits virus replication and polymerase activity in cultured cells and decreases virulence in mouse models. Therefore, our study demonstrates that PA-X protein acts as a negative virulence regulator for classical H1N1 swine influenza virus and decreases virulence by inhibiting viral replication and polymerase activity, deepening our understanding of the pathogenesis of swine influenza virus.
分类号: S9
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