Ultrasonic Assisted Extraction of Paclitaxel from Taxus x media Using Ionic Liquids as Adjuvants: Optimization of the Process by Response Surface Methodology

文献类型： 外文期刊

第一作者： Tan, Zhijian

作者： Tan, Zhijian;Wang, Chaoyun;Zhou, Wanlai;Yang, Yuanru;Wang, Hongying;Yi, Yongjian;Tan, Zhijian;Wang, Chaoyun;Zhou, Wanlai;Yang, Yuanru;Wang, Hongying;Yi, Yongjian;Li, Qiao;Li, Fenfang

作者机构：

关键词： paclitaxel;ionic liquids;adjuvants;ultrasonic assisted extraction

期刊名称：MOLECULES （ 影响因子：4.411； 五年影响因子：4.587 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： (1) Background: Ionic liquids (ILs) are considered "green" solvents and have been widely used in the extraction and separation field in recent years; (2) Methods: In this study, some common ILs and functionalized magnetic ionic liquids (MILs) were used as adjuvants for the solvent extraction of paclitaxel from Taxus x media (T. x media) using methanol solution. The extraction conditions of methanol concentration, IL type and amount, solid-liquid ratio, extraction temperature, and ultrasonic irradiation time were investigated in single factor experiments. Then, three factors of IL amount, solid-liquid ratio, and ultrasonic irradiation time were optimized by response surface methodology (RSM); (3) Results: The MIL [C4MIM] FeCl3Br was screened as the optimal adjuvant. Under the optimization conditions of 1.2% IL amount, 1:10.5 solid-liquid ratio, and 30 min ultrasonic irradiation time, the extraction yield reached 0.224 mg/g; and (4) Conclusions: Compared with the conventional solvent extraction, this ultrasonic assisted extraction (UAE) using methanol and MIL as adjuvants can significantly improve the extraction yield, reduce the use of methanol, and shorten the extraction time, which has the potentiality of being used in the extraction of some other important bioactive compounds from natural plant resources.

分类号： O62

  • 相关文献

[1]Optimization of ultrasonic extraction by response surface methodology combined with ultrafast liquid chromatography-ultraviolet method for determination of four iridoids in Gentiana rigescens. Pan, Yu,Zhang, Ji,Zuo, Zhi-Tian,Jin, Hang,Wang, Yuan-Zhong,Li, Wan-Yi,Pan, Yu,Shen, Tao. 2015

[2]Ultrasonic Extraction of Antioxidants from Chinese Sumac (Rhus typhina L.) Fruit Using Response Surface Methodology and Their Characterization. Lai, Jixiang,Wang, Huifang,Wang, Donghui,Fang, Fang,Wang, Fengzhong,Wu, Tao.

[3]Ultrasmall Graphene Oxide Supported Gold Nanoparticles as Adjuvants Improve Humoral and Cellular Immunity in Mice. Cao, Yuhua,Ma, Yufei,Zhang, Mengxin,Wang, Haiming,Tu, Xiaolong,Shen, He,Dai, Jianwu,Zhang, Zhijun,Cao, Yuhua,Zhang, Mengxin,Tu, Xiaolong,Shen, He,Wang, Haiming,Guo, Huichen.

[4]Positive role for rApxIVN in the immune protection of pigs against infection by Actinobacillus pleuropneumoniae. Wang, Chunlai,Wang, Yong,Shao, Meili,Si, Wei,Liu, Huifang,Chang, Yuehong,Peng, Wei,Kong, Xiangang,Liu, Siguo,Shao, Meili.

[5]Adjuvants for foot-and-mouth disease virus vaccines: recent progress. Cao, Yimei. 2014

[6]Inactivated vaccine with adjuvants consisting of pattern recognition receptor agonists confers protection against avian influenza viruses in chickens. Tang, Yinghua,Lu, Jihu,Wu, Peipei,Liu, Zhenxing,Tian, Zhen,Zha, Guofei,Chen, Hui,Wang, Qiaochu,Hou, Fengxiang,Hou, Jibo,Tang, Yinghua,Wang, Qiaoxiu,Kang, Sang-Moo.

[7]Progress of Lipase-Catalyzed Ester Synthesis in Ionic Liquid. Li Jing,Wang Jun,Zhang Leixia,Gu Shuangshuang,Wu Fuan,Guo Yuewei,Wu Fuan,Guo Yuewei. 2012

[8]Comparison of Structural Modification of Sugarcane Bagasse Cellulose Regenerated from Three Imidazolium-Based Ionic Liquids. Cui, Lihong,Wei, Xiaoyi,Fu, Tiaokun,Chang, Gang,Feng, Qin,Tang, Bing. 2017

[9]Pyrrolidinium Ionic Liquids as Effective Solvents for Lignin Extraction and Enzymatic Hydrolysis of Lignocelluloses. Hu, Xiao-Mei,Li, Shuang,Ma, Hui-Hui,Zhang, Bi-Xian,Gao, Yun-Fei. 2016

[10]Assessment of the cytotoxicity of ionic liquids on Spodoptera frugiperda 9 (Sf-9) cell lines via in vitro assays. Zeng, Liangbin,Wang, Chaoyun,Yang, Yuanru,Zhou, Wanlai,Tan, Zhijian,Zeng, Liangbin,Wang, Chaoyun,Yang, Yuanru,Zhou, Wanlai,Tan, Zhijian,Wu, Shuanggen,Li, Fenfang. 2018

[11]Ionic-liquid-based, manual-shaking- and ultrasound-assisted, surfactant-enhanced emulsification microextraction for the determination of three fungicide residues in juice samples. Chen, Xiaochu,You, Xiangwei,Liu, Fengmao,Hou, Fan,Zhang, Xu,You, Xiangwei.

[12]Factors Governing the Pretreatment Process of Lignocellulosic Biomass in an Acidic Pyrrolidonium Ionic Liquid. Hu, Xiao-Mei,Wang, Fu-Ling,Ma, Hui-Hui,Hu, Bao-Zhong,Zhang, Bi-Xian,Gao, Yun-Fei,Hu, Bao-Zhong. 2016

[13]Extraction, Preconcentration and Isolation of Flavonoids from Apocynum venetum L. Leaves Using Ionic Liquid-Based Ultrasonic-Assisted Extraction Coupled with an Aqueous Biphasic System. Tan, Zhijian,Yi, Yongjian,Wang, Hongying,Zhou, Wanlai,Wang, Chaoyun.

[14]Knoevenagel Reactions in Ionic Liquids. Hu Xiao-Mei,Xiao Yi-Bo,Gao Yun-Fei,Zhang Bi-Xian,Zhao Yang. 2012

[15]Regeneration of bagasse cellulose by ionic liquid. Li, Jihua,Tang, Yongfu,Chen, Jiacui,Cao, Yupo,Huang, Maofang,Fu, Tiaokun,Su, Junbo. 2011

[16]An efficient process for lignin extraction and enzymatic hydrolysis of corn stalk by pyrrolidonium ionic liquids. Ma, Hui-Hui,Zhang, Peng,Li, Shuang,Hu, Xiao-Mei,Zhang, Bi-Xian,Gao, Yun-Fei.

[17]Phosphoric-based ionic liquids as solvents to separate the azeotropic mixture of ethanol and hexane. Cai, Fufeng,Wang, Yuan,Wang, Fei,Xiao, Guomin,Zhao, Min.

[18]Application of ionic liquid-based surfactants in the microwave-assisted extraction for the determination of four main phloroglucinols from Dryopteris fragrans. Li, Xiao-Juan,Zu, Yuan-Gang,Wang, Wei,Luo, Meng,Gu, Cheng-Bo,Zhao, Chun-Jian,Fu, Yu-Jie,Li, Xiao-Juan,Yu, Hui-Min,Gao, Chang.

[19]Study of chiral ionic liquid as stationary phases for GC. Sun, Xiaojie,Xu, Jiakun,Zhai, Yuxiu,Sun, Xiaojie,Zhai, Yuxiu,Zhao, Xiaojie,Xing, Jun.

[20]Two-Stage Prediction of the Effects of Imidazolium and Pyridinium Ionic Liquid Mixtures on Luciferase. Ge, Hui-Lin,Su, Bing-Xia,Ge, Hui-Lin,Liu, Shu-Shen,Zhu, Xiang-Wei.

作者其他论文 更多>>

微信小程序