Generation of a Floxed Allele of the Mouse MicroRNA-200 Clusters

文献类型： 外文期刊

第一作者： Ren, Hongyan

作者： Ren, Hongyan;Bi, Yanzhen;Zheng, Xinmin;Tao, Cong;Li, Kui

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关键词： MicroRNA-200s;Gene targeting;Cre-loxp

期刊名称：APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY （ 影响因子：2.926； 五年影响因子：2.685 ）

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收录情况： SCI

摘要： MicroRNA-8 and its target gene, u-shaped (ush), regulate body size in Drosophila. As the mouse homolog of the Drosophila miR-8, whether the miR-200 family has similar functions and how they perform their regulatory roles in body size control is unknown. In order to discover the biological function of the miR-200s in vivo, we generated mice lacking the miR-200b/200a/429 gene cluster using the Cre/loxp system. miR-200b/200a/429 null mutant mice were viable, fertile, and showed normal development.

分类号： Q5

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