Sophora subprosrate polysaccharide inhibited cytokine/chemokine secretion via suppression of histone acetylation modification and NF-kappa b activation in PCV2 infected swine alveolar macrophage

文献类型： 外文期刊

第一作者： Tan, Hong-Lian

作者： Tan, Hong-Lian;Gu, Li-Yuan;Song, Man-Ling;Wu, Yuan-Ying;Wei, Ying-Yi;Hu, Ting-Jun;Peng, Jian-Bo;Lang, Zong-Bao

作者机构：

关键词： Sophora subprosrate polysaccharide;Inflammatory cytokines;PCV2

期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：6.953； 五年影响因子：6.737 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： In the present study, effect of Sophora subprosrate polysaccharide on PCV2 infection-induced inflammation and histone acetylation modification in swine alveolar macrophage 3D4/2 cells was described for the first time. The relationship between histone acetylation modifications and inflammation response was investigated. The results showed that PCV2 infection induced inflammation by promoting the secretion of TNF-alpha, IL -1 beta, IL-6 and IL-10 in 3D4/2 cells. The production of TNF-alpha, IL-1 beta and IL-6 and their mRNA expression levels markedly decreased while the level and mRNA expression of IL-10 were elevated when the cells were treated with Sophora subprosrate polysaccharide. The SSP also decreased the activity of HATs, histone H3 acetylation (Ac-H3) and histone H4 acetylation (Ac-H4), p65 phosphorylation (P-p65) in the cells infected with PCV2 while HDACs activity was down-regulated, which involved in the inhibitory effect of SSP on histone acetylation and NF-kappa B signaling pathways activation. Down-regulation of HAT1 mRNA expression and up-regulation of HDAC1 mRNA expression further support the inhibitory effect of SSP on histone acetylation. In conclusion, Sophora subprosrate polysaccharide antagonized inflammatory responses induced by PCV2, via mechanisms involved in histone acetylation and NF-kappa B signaling pathways. (C) 2017 Elsevier B.V. All rights reserved.

分类号： Q71

  • 相关文献

[1]Promotion of Sophora subprosrate polysaccharide on nitric oxide and interleukin-2 production in murine T lymphocytes: implicated Ca2+ and protein kinase C. Hu, TJ,Zheng, RL. 2004

[2]Anti-inflammatory and hepatoprotective effects of glycyrrhetinic acid on CCl4-induced damage in precision-cut liver slices from Jian carp (Cyprinus carpio var. jian) through inhibition of the nf-kB pathway. Cao, Liping,Ding, Weidong,Jia, Rui,Du, Jingliang,Wang, Tao,Zhang, Chunyun,Gu, Zhengyan,Yin, Guojun,Cao, Liping,Ding, Weidong,Jia, Rui,Du, Jingliang,Wang, Tao,Zhang, Chunyun,Gu, Zhengyan,Yin, Guojun.

[3]Effects of dietary supplementation with N-acetyl cysteine on antioxidant capacities and the expression of inflammatory cytokines in weaned piglets. Guo, Qi,Cai, Xuan,Xu, Congcong,Luo, Zhen,Sheng, Yongshuai,Bao, Jian,Xu, Jianxiong,Guo, Qi,Cai, Xuan,Xu, Congcong,Luo, Zhen,Sheng, Yongshuai,Bao, Jian,Xu, Jianxiong,Chen, Xiaolian,Xu, Jianxiong. 2016

[4]Bone marrow-derived mesenchymal stem cells in three-dimensional culture promote neuronal regeneration by neurotrophic protection and immunomodulation. Han, Sufang,Li, Xing,Xiao, Zhifeng,Han, Jin,Zhao, Yannan,Yin, Yanyun,Chen, Bing,Dai, Jianwu,Wang, Bin,Li, Xing,Fang, Yongxiang.

[5]Regulation network of serum cytokines induced by tuberculosis-specific antigens reveals biomarkers for tuberculosis diagnosis. Wei, M.,Wu, Z. Y.,Lin, J. H.,Xie, Y. Q.,Su, H.,Zhou, W.,Li, Y.,Qian, Z. X.. 2015

[6]Effects of carbon tetrachloride on oxidative stress, inflammatory response and hepatocyte apoptosis in common carp (Cyprinus carpio). Jia, Rui,Wang, Jia-Hao,Liu, Ying-Juan,Xu, Pao,Yin, Guo-Jun,Jia, Rui,Cao, Li-Ping,Du, Jin-Liang,Xu, Pao,Yin, Guo-Jun,Cao, Li-Ping,Du, Jin-Liang,Yin, Guo-Jun,Jeney, Galina.

[7]Effects of PEGylated porcine glucagon-like peptide-2 therapy in weaning piglets challenged with lipopolysaccharide. Qi, Ke-ke,Wu, Jie,Xu, Zi-wei.

[8]Development of real-time PCR assay for detection of porcine circovirus-like virus P1 in domestic pigs in China. He, Kong-wang,Lu, Cheng-ping,He, Kong-wang,Wen, Li-bin,Wang, Yong-shan. 2015

[9]Development of recombinant porcine parvovirus-like particles as an antigen carrier formed by the hybrid VP2 protein carrying immunoreactive epitope of porcine circovirus type 2. Pan, Qunxing,He, Kongwang,Pan, Qunxing,Huang, Kehe. 2008

[10]Nitric oxide-generating compound GSNO suppresses porcine circovirus type 2 infection in vitro and in vivo. Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang,Liu, Chuanmin,Wen, Libin,Xiao, Qi,He, Kongwang. 2017

[11]Evaluation of the enhancing ability of three adjuvants for DNA vaccination using the porcine circovirus type 2 ORF2 (capsid) gene in mice. Fu, Fang,Lang, Yuekun,Li, Xuesong,Chai, Zheng,Liu, Siguo,Tian, Huabin,Li, Haizhong,Wang, Wei,Chen, Xin,Li, Xi,Li, Xuesong,Tong, Guangzhi.

[12]Co-expression of Ubiquitin gene and capsid protein gene enhances the potency of DNA immunization of PCV2 in mice. Fu, Fang,Li, Xuesong,Lang, Yuekun,Li, Xi,Li, Xuesong,Yang, Yuju,Tong, Guangzhi,Li, Guoxin,Zhou, Yanjun,Li, Xi. 2011

[13]Role of Chinese herbal medicinal ingredients in secretion of cytokines by PCV2-induced endothelial cells. Hu, Yiyi,He, Kongwang,Wang, Xiaomin. 2016

作者其他论文 更多>>

微信小程序