Synthesis and antibacterial activity of oxime ester derivatives containing 1,2,4-triazole or 1,3,4-oxadiazole moiety

文献类型： 外文期刊

第一作者： Wang, Xiaobin

作者： Wang, Xiaobin;Zhong, Xinmin;Zhu, Xuesong;Li, Qin;Zhang, Juping;Ruan, Xianghui;Xue, Wei;Wang, Hua

作者机构：

关键词： 1;2;4-Triazole;1;3;4-Oxadiazole;Oxime ester;Antibacterial activity

期刊名称：CHEMICAL PAPERS （ 影响因子：2.097； 五年影响因子：1.831 ）

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收录情况： SCI

摘要： A series of oxime ester derivatives containing 1,2,4-triazole or 1,3,4-oxadiazole moiety were designed and synthesized, and their antibacterial activities in vitro against Xanthomonas axonopodis pv. citri (Xac) and Xanthomonas oryzae pv. oryzae (Xoo) were evaluated. The bioassays showed that all the title compounds exhibit potent antibacterial activity against Xac and Xoo. In particular, the compounds 4a, 5a, 5b, 5c, 5d, 5h and 5i exhibited remarkable antibacterial activity against Xoo, with the EC50 values ranging from 15.15 to 49.34 mu g/mL, which were superior to that of bismerthiazol (92.61 mu g/mL). This study indicated that oxime ester derivatives containing 1,2,4-triazole or 1,3,4-oxadiazole moiety may be used as potential alternative templates in the search for novel antibacterial agents.

分类号： O6

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