Effects of Pu-erh ripened tea on hyperuricemic mice studied by serum metabolomics

文献类型: 外文期刊

第一作者: Zhao, Ran

作者: Zhao, Ran;Chen, Dong;Wu, Hualing;Zhao, Ran;Zhao, Ran;Chen, Dong;Wu, Hualing

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关键词: Pu-erh ripened tea;Metabolomics;GC–MS;Hyperuricemia

期刊名称:JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES ( 影响因子:3.205; 五年影响因子:3.068 )

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收录情况: SCI

摘要: Highlights?Serum metabolomics based on GC–MS was employed in this study.?Twelve potential biomarkers associated with hyperuricemia were identified.?Pu-erh ripened tea caused anti-hyperuricemia in mice.?A mechanism of Pu-erh ripened tea effects may be modifying amino acid metabolism.AbstractTo evaluate effects of Pu-erh ripened tea in hyperuricemic mice, a mouse hyperuricemia model was developed by oral administration of potassium oxonate for 7 d. Serum metabolomics, based on gas chromatography–mass spectrometry, was used to generate metabolic profiles from normal control, hyperuricemic and allopurinol-treated hyperuricemic mice, as well as hyperuricemic mice given Pu-erh ripened tea at three doses. Pu-erh ripened tea significantly lowered serum uric acid levels. Twelve potential biomarkers associated with hyperuricemia were identified. Pu-erh ripened tea and allopurinol differed in their metabolic effects in the hyperuricemic mice. Levels of glutamic acid, indolelactate, L-allothreonine, nicotinoylglycine, isoleucine,l-cysteine and glycocyamine, all involved in amino acid metabolism, were significantly changed in hyperuricemic mice treated Pu-erh ripened tea. Thus, modulating amino acid metabolism might be the primary mechanism of anti-hyperuricemia by Pu-erh ripened tea.]]>

分类号: Q503

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