Effects of Hypericum perforatum extract on the endocrine immune network factors in the immunosuppressed Wistar rat

文献类型： 外文期刊

第一作者： Hao, Baocheng

作者： Hao, Baocheng;Hu, Xiaoyan;Wang, Xuehong;Liu, Yu;Yang, Zhen;Guo, Wenzhu;Shang, Ruofeng;Liang, Jianping

作者机构：

关键词： Dopamine (DA);Endocrine immune network factors;Hypericum perforatum extract;Interleukin-1 (IL-1);Norepinephrine (NE);5-hydroxytryptamine(5-HT)

期刊名称：INDIAN JOURNAL OF ANIMAL RESEARCH （ 影响因子：0.44； 五年影响因子：0.543 ）

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收录情况： SCI

摘要： The study aimed to investigate the effects of Hypericum perforatum extract on the endocrine immune network factors in the immunosuppressed rat. Wistar rats were used to establish an immunosuppression model. Immunosuppressed rats received Hypericum perforatum extract suspension for 7 days at doses of 600 mg/kg (containing hyperforin at 7.2mg/kg). Endocrine immune network factors including IL-1, DA, NE, and 5-HT were determined on day 8. The results indicated that Hypericum perforatum extract affects the endocrine immune network through decreasing endogenous IL-1, dopamine (DA), norepinephrine (NE), and 5-hydroxytryptamine (5-HT) levels. Hyperforin reverses immune suppression through enhancing DA levels to inhibit B cells while promoting T cell and macrophage functions to recover immune function.

分类号： S8

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