The presence of oleate stabilized ZnO nanoparticles (NPs) and reduced the toxicity of aged NPs to Caco-2 and HepG2 cells

文献类型： 外文期刊

第一作者： Fang, Xin

作者： Fang, Xin;Jiang, Leying;Gong, Yu;Li, Juan;Cao, Yi;Liu, Liangliang;Cao, Yi

作者机构：

关键词： Oleate (OA);ZnO nanoparticle (NP);Interaction;Caco-2?cells;HepG2 cells

期刊名称：CHEMICO-BIOLOGICAL INTERACTIONS （ 影响因子：5.192； 五年影响因子：4.61 ）

ISSN：

年卷期：

页码：

收录情况： SCI

摘要： Abstract The presence of food components may alter the colloidal aspects and toxicity of nanoparticles (NPs). In this study, the toxicity of ZnO NPs to Caco-2 and HepG2 cells was assessed, with the emphasis on the interactions between ZnO NPs and oleate (OA). The presence of OA increased UV–Vis spectra and hydrodynamic sizes, decreased Zeta potential, and markedly reduced the release of Zn ions from the dissolution of ZnO NPs, which combined indicated that OA could coat ZnO NPs and stabilize ZnO NPs. Exposure to ZnO NPs significantly induced cytotoxicity to Caco-2 and HepG2 cells, associated with increased intracellular Zn ions but not superoxide. When OA was added to the freshly prepared ZnO NP suspensions, the cytotoxicity, intracellular Zn ions and superoxide induced by ZnO NPs were not significantly affected. However, when ZnO NPs were aged for 24?h with the presence of OA, the cytotoxicity of ZnO NPs to Caco-2 and HepG2 cells was significantly reduced, associated with a reduction of intracellular Zn ions. The results from this study suggested that the presence of OA could increase colloidal stability of ZnO NPs and consequently reduce the toxicity of ZnO NPs after aging associated with reduced accumulation of intracellular Zn ions. Highlights ? The interactions between ZnO NPs and oleate (OA) were studied. ? OA could coat ZnO NPs and increase the colloidal stability. ? ZnO NP were toxic to Caco-2 and HepG2 cells associated with intracellular Zn ions. ? OA reduced the toxicity of aged but not freshly prepared ZnO NPs.

分类号： Q5

  • 相关文献

[1]The Interactions between ZnO Nanoparticles (NPs) and alpha-Linolenic Acid (LNA) Complexed to BSA Did Not Influence the Toxicity of ZnO NPs on HepG2 Cells. Zhou, Yiwei,Fang, Xin,Xiao, Aiping,Liu, Liangliang,Cao, Yi,Zhou, Yiwei,Fang, Xin,Gong, Yu,Xie, Yixi,Cao, Yi. 2017

[2]The presence of palmitate affected the colloidal stability of ZnO NPs but not the toxicity to Caco-2 cells. Gong, Yu,Li, Juan,Cao, Yi,Liu, Liangliang,Cao, Yi. 2017

[3]Thapsigargin induces apoptosis when autophagy is inhibited in HepG2 cells and both processes are regulated by ROS-dependent pathway. Wang, Congcong,Tang, Shusheng,Zhao, Dongxu,Zhang, Chaoming,Zhang, Shen,Deng, Sijun,Zhou, Yan,Xiao, Xilong,Wang, Congcong,Li, Tao.

[4]Effect of Cr(VI) on Fe(III) reduction in three paddy soils from the Hani terrace field at high altitude. Li, Xiao-min,Liu, Tong-xu,Li, Fang-bai,Zhang, Nai-ming,Ren, Guo,Li, Xiao-min,Li, Yong-tao. 2012

[5]Overexpression of OsCIPK30 Enhances Plant Tolerance to Rice stripe virus. Liu, Zhiyang,Li, Xuejuan,Sun, Feng,Zhou, Tong,Zhou, Yijun,Liu, Zhiyang,Li, Xuejuan,Sun, Feng,Zhou, Tong,Zhou, Yijun. 2017

[6]Which Factors Determine Metal Accumulation in Agricultural Soils in the Severely Human-Coupled Ecosystem?. Xu, Li,Cao, Shanshan,Wang, Jihua,Lu, Anxiang,Xu, Li,Cao, Shanshan,Wang, Jihua,Lu, Anxiang. 2016

[7]Mouse hepatitis virus nucleocapsid protein interacts receptor for activated C kinase1, and regulates AKT signal pathway. Zhang, Pengju,Wu, Xinghong,Wang, Jun,Long, Miao. 2017

[8]Functional Genomic Analysis of Aspergillus flavus Interacting with Resistant and Susceptible Peanut. Wang, Houmiao,Lei, Yong,Yan, Liying,Wan, Liyun,Ren, Xiaoping,Chen, Silong,Jiang, Huifang,Liao, Boshou,Wang, Houmiao,Lei, Yong,Yan, Liying,Wan, Liyun,Ren, Xiaoping,Chen, Silong,Jiang, Huifang,Liao, Boshou,Dai, Xiaofeng,Guo, Wei. 2016

[9]Nonstructural protein P7-2 encoded by Rice black-streaked dwarf virus interacts with SKP1, a core subunit of SCF ubiquitin ligase. Wang, Qian,Wang, Qian,Tao, Tao,Han, Yanhong,Chen, Xiangru,Fan, Zaifeng,Li, Dawei,Yu, Jialin,Han, Chenggui,Wang, Qian,Tao, Tao,Han, Yanhong,Chen, Xiangru,Fan, Zaifeng,Li, Dawei,Yu, Jialin,Han, Chenggui. 2013

[10]F(0)ATP synthase b-chain of Litopenaeus vannamei involved in White Spot Syndrome Virus infection. Li, Qian,Liu, Qing-hui,Huang, Jie,Li, Qian. 2013

[11]Study on Interaction between Coomassie Brilliant Blue G-250 and Bovine Serum Albumin by Fluorescence Spectroscopy and Molecular Modeling. Wang Yong-gang,Yang Guang-rui,Leng Fei-fan,Ma Jian-zhong,Ma Xue-qing,Wang Xiao-li. 2017

[12]Genomic prediction with epistasis models: on the marker-coding-dependent performance of the extended GBLUP and properties of the categorical epistasis model (CE). Martini, Johannes W. R.,Gao, Ning,Cardoso, Diercles F.,Erbe, Malena,Simianer, Henner,Gao, Ning,Cardoso, Diercles F.,Cardoso, Diercles F.,Erbe, Malena,Cantet, Rodolfo J. C.. 2017

[13]Interaction of heat shock protein 90 B1 (Hsp90B1) with liposome reveals its potential role in protection the integrity of lipid membranes. Li, Pengpeng,Zhang, Muhan,Zou, Ye,Sun, Zhilan,Sun, Chong,Geng, Zhiming,Xu, Weimin,Wang, Daoying. 2018

[14]Porcine Viperin protein inhibits the replication of classical swine fever virus (CSFV) in vitro. Li, Wenliang,Mao, Li,Yang, Leilei,Hao, Fei,Zhang, Wenwen,Jiang, Jieyuan,Cao, Yongguo,Zhou, Bin,Han, Linxiao,Lin, Tao. 2017

[15]Metabolomics Investigation of an Association of Induced Features and Corresponding Fungus during the Co-culture of Trametes versicolor and Ganoderma applanatum. Xu, Xiao-Yan,Shen, Xiao-Ting,Yuan, Xiao-Jie,Zhu, Li-Ping,Yang, Song,Zhou, Yuan-Ming,Fan, Huan,Du, Feng-Yu,Sadilek, Martin,Yang, Jie,Qiao, Bin,Yang, Song. 2018

[16]Effects of Bacillus thuringiensis toxin Cry1Ac and Beauveria bassiana on Asiatic corn borer (Lepidoptera : Crambidae). Ma, Xiao-Mu,Liu, Xiao-Xia,Ning, Xia,Zhang, Bo,Han, Fei,Guan, Xiu-Min,Zhang, Qing-Wen,Tan, Yun-Feng. 2008

[17]Nine facultative endosymbionts in aphids. A review. Hatt, Severin,He, Kanglai,Chen, Julian,Wang, Zhenying,Guo, Jianqing,Hatt, Severin,Francis, Frederic,Guo, Jianqing,Hatt, Severin. 2017

[18]Effect of B-complex vitamins on the antifatigue activity and bioavailability of ginsenoside Re after oral administration. Chen, Yin Bin,Wang, Yu Fang,Hou, Wei,Wang, Ying Ping,Xiao, Sheng Yuan,Wang, Jia,Zheng, Si Wen,Zheng, Pei He,Xiao, Sheng Yuan,Fu, Yang Yang. 2017

[19]The interaction of soybean reticulon homology domain protein (GmRHP) with Soybean mosaic virus encoded P3 contributes to the viral infection. Cui, Xiaoyan,Lu, Lu,Wang, Ying,Yuan, Xingxing,Chen, Xin,Wang, Ying. 2018

[20]Protein-protein interactions in two potyviruses using the yeast two-hybrid system. Lin, Lin,Shi, Yuhong,Luo, Zhaopeng,Lu, Yuwen,Zheng, Hongying,Yan, Fei,Chen, Jiong,Chen, Jianping,Lin, Lin,Wu, Yunfeng,Adams, M. J.. 2009

作者其他论文 更多>>

微信小程序