HIV-1 and BLV are insensitive to SERINC5 restriction under the cell-cell infection

文献类型： 外文期刊

第一作者： Yu, Changqing

作者： Yu, Changqing;Jiang, Faming;Li, Yujing;Yang, Dan;Xu, Chao;Xian, Yuanhua;Yu, Changqing;Li, Sunan;Khan, Ilyas;Xia, Changyou;Zhang, He;Li, Qiushui;Tokunaga, Kenzo;Li, Nan

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关键词： serine incorporator 5; retrovirus; HIV-1; BLV; cell-cell; restriction

期刊名称：MICROBIOLOGY SPECTRUM （ 影响因子：3.8； 五年影响因子：4.1 ）

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年卷期： 2025 年 13 卷 3 期

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收录情况： SCI

摘要： Serine incorporator 5 (SERINC5, SER5) suppresses viral cell-free infection. However, its antiviral potency under viral cell-cell infection is not examined yet. Here, we established the in vitro cell-cell infection systems to assess SER5's antiviral activity on HIV-1 and bovine leukemia virus (BLV). Our results showed SER5 from different mamma lian species, including Homo sapiens, Bos taurus, and Felis catus, was capable of signifi cantly inhibiting HIV-1 cell-free infection. However, these SER5s were unable to restrict HIV-1 cell-cell infection. Intriguingly, Ebola virus glycoprotein-mediated pseudoviral cell-free infection was greatly enhanced by Homo sapiens and Bos taurus SER5. Notably, BLV was also insensitive to SER5-mediated restriction under the cell-cell infection. In addition, BLV envelope glycoproteins, which contained one glycosylation variation, were not restricted by SER5 in the model of cell-cell infection. Overall, our results indicated SER5 was ineffective against HIV-1 and BLV under the cell-cell infection, which was utilized by them to circumvent SER5-imposed restriction in vitro and may aid their transmission in vivo.

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