A supergene controls facultative diapause in the crop pest Helicoverpa armigera

文献类型： 外文期刊

第一作者： Jin, Minghui

作者： Jin, Minghui;Peng, Yan;Peng, Jie;Yu, Songmiao;Wu, Chao;Zhu, Jingyun;Xu, Qi;Wang, Hongru;Xiao, Yutao;Yang, Xianming;Wu, Kongming;Infante, Oscar

作者机构：

关键词： Input module; Amino acid substitution; Diapause induction conditions; changes; Highlights

期刊名称：CELL REPORTS （ 影响因子：6.9； 五年影响因子：8.1 ）

ISSN： 2211-1247

年卷期： 2024 年 43 卷 11 期

页码：

收录情况： SCI

摘要： Many insect species, including the economically important pest Helicoverpa armigera, avoid unfavorable conditions by suspending development. This form of phenotypic plasticity-facultative diapause-is a complex trait, though its evolution and intricate genetic architecture remain poorly understood. To investigate how such a polygenic trait could be locally adapted, we explore its genetic architecture. We map a large-effect diapause-associated locus to the Z chromosome by crossing high- and low-latitude populations. By generating multiple chromosome-scale assemblies, we identify an '5.93-Mb chromosomal inversion that constitutes the locus. Within this inversion, 33 genes harbor divergent non-synonymous mutations, notably including three circadian rhythm genes: Period, Clock, and Cycle. CRISPR-Cas9 knockout experiments confirm that each gene is independently essential for pupal diapause. Thus, a diapause supergene arose within H. armigera via a Z chromosome inversion, enabling local climatic adaptation in this economically important crop pest.

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