Structural elucidation of a polysaccharide from &ITFlammulina velutipes &ITand its immunomodulation activities on mouse B lymphocytes
文献类型： 外文期刊
第一作者： Wang, Wen-Han
作者： Wang, Wen-Han;Zhang, Jing-Song;Feng, Ting;Lin, Chi-Chung;Jia, Wei;Feng, Ting;Bao, Hai-Ying;Deng, Jing;Fan, Hua;Yu, Wen-Juan
作者机构：
期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）
ISSN： 2045-2322
年卷期： 2018 年 8 卷
页码：
收录情况： SCI
摘要： A novel polysaccharide FVPB2 was purified from fruiting bodies of Flammulina velutipes. Its structure was elucidated by monosaccharide composition and methylation analyses, UV-Visible and FTIR spectroscopy as well as NMR. FVPB2 was a homogeneous heteropolysaccharide (molecular weight -1.50 x 10(4) Da) containing D-galactose, D-mannose, L-fucose, and D-glucose at molar ratio of 1.9:1.2:1:2.5. In vitro immunomodulatory studies showed FVPB2 induced proliferation of mouse spleen lymphocytes in a dose-dependent manner. The levels of IgM and IgG, secreted by B cells, increased after FVPB2 treatment. So FVPB2 has potential to be a new important immunomodulatory nutraceutical.
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