Fabrication and stabilization of biocompatible selenium nanoparticles by carboxylic curdlans with various molecular properties

文献类型： 外文期刊

第一作者： Yan, Jing-Kun

作者： Yan, Jing-Kun;Qiu, Wen-Yi;Wang, Yao-Yao;Wang, Wen-Han;Yang, Yan;Zhang, He-Nan;Wang, Wen-Han;Yang, Yan;Zhang, He-Nan

作者机构：

关键词： Carboxylic curdlan;Selenium nanoparticles;Characterization;Antioxidant activity;Cytotoxicity

期刊名称：CARBOHYDRATE POLYMERS （ 影响因子：9.381； 五年影响因子：8.678 ）

ISSN： 0144-8617

年卷期： 2018 年 179 卷

页码：

收录情况： SCI

摘要： In this study, carboxylic curdlans (Cur-4, Cur-8, and Cur-24) with different molecular properties and chain conformations were used as stabilizer and capping agent to fabricate stable and water-dispersible selenium nanoparticles (SeNPs). Results showed that molecular properties and chain conformations of carboxylic curdlans remarkably influenced the size, morphology, structure, and stability of SeNPs and the carboxylic curdlan was ligated to SeNPs via O-H center dot center dot center dot Se interaction. The as-prepared SeNPs was amorphous and showed homogeneous and monodisperse spherical structure with size of similar to 50-90 nm. The Cur-8-decorated SeNPs (SeNPs@Cur-8) exhibited smaller particle size (similar to 56 nm) and greater stability than those of the others. The carboxylic curdlan-stabilized SeNPs exhibited excellent antioxidant capacities compared to the control SeNPs. Specifically, SeNPs@Cur-8 with smaller particle size possessed strong antioxidant efficacy. SeNPs@Cur-8 also exhibited low cytotoxic activity against SPCA-1 and HeLa cell lines in vitro.

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