Infectivity of a genotype 4 hepatitis E virus cDNA clone by intrahepatic inoculation of laboratory rats
文献类型: 外文期刊
第一作者: Zhu, Yumin
作者: Zhu, Yumin;Yu, Xiaoming;Si, Fusheng;Yu, Ruisong;Dong, Shijuan;Li, Zhen;Zhu, Yumin;Yu, Ruisong;Dong, Shijuan;Li, Zhen;Yu, Xiaoming;Zhang, Yuanshu;Si, Fusheng;Ni, Yanyan;Huang, Yaowei
作者机构:
关键词: Hepatitis E virus (HEV);Infectious clone;Genotype 4;Rat animal model
期刊名称:VETERINARY MICROBIOLOGY ( 影响因子:3.293; 五年影响因子:3.599 )
ISSN: 0378-1135
年卷期: 2013 年 166 卷 3-4 期
页码:
收录情况: SCI
摘要: A cDNA clone of a genotype 4 swine hepatitis E virus (HEV) strain (SAAS-FX17), identified in Shanghai, has been constructed. Capped RNA transcripts were prepared in vitro and shown to be replication-competent in Huh7 cells. Sprague-Dawley (SD) rats administered the RNA transcripts by intrahepatic inoculation developed active infections as evidenced by fecal virus shedding and sero-conversion to anti-HEV. The former was first detected between 23 and 30 days post-inoculation (dpi) and persisted until 45 dpi. Sera of rats inoculated with RNA transcripts became anti-HEV positive between 30 and 40 dpi, and reverted to anti-HEV negative at 52 dpi. Our data indicate for the first time that intrahepatic inoculation of rats with RNA transcripts of an HEV cDNA clone may serve as an alternative animal model for HEV research. (C) 2013 Elsevier B.V. All rights reserved.
分类号:
- 相关文献
作者其他论文 更多>>
-
Single-cell transcriptome atlas of lamprey exploring Natterin- induced white adipose tissue browning
作者:Pang, Yue;Du, Zeyu;Zhang, Jin;Lu, Jiali;Li, Jun;Dong, Xinrui;Zhao, Zhisheng;Chuan, Shunqin;Sun, Mingjie;Li, Qingwei;Pang, Yue;Du, Zeyu;Zhang, Jin;Lu, Jiali;Li, Jun;Dong, Xinrui;Zhao, Zhisheng;Chuan, Shunqin;Sun, Mingjie;Li, Qingwei;Qin, Yating;Liu, Qun;Han, Kai;Yuan, Zengbao;Pan, Shanshan;Xu, Mengyang;Wang, Dantong;Li, Zhen;Chen, Yadong;Song, Yue;Zhan, Liping;Cui, Wei;Wang, Jun;Fan, Guangyi;Qin, Yating;Liu, Qun;Han, Kai;Fan, Guangyi;Qin, Yating;Liu, Qun;Han, Kai;Song, Yue;Qin, Yating;Fan, Guangyi;Yuan, Zengbao;Xu, Mengyang;Wang, Dantong;Gu, Ying;Yang, Huanming;Xu, Xun;Liu, Xin;Fan, Guangyi;Xu, Mengyang;Fan, Guangyi;Li, Shuo;Zhang, Zhe;Ni, Ming;Jia, Xiaodong;Xia, Zhangyong;Yue, Zhen;Fan, Guangyi;Gu, Ying;Yang, Huanming;Xu, Xun;Liu, Xin
关键词:
-
The highly allo-autopolyploid modern sugarcane genome and very recent allopolyploidization in Saccharum
作者:Zhang, Jisen;Hua, Xiuting;Wang, Baiyu;Yu, Zehuai;Gao, Ruiting;Wang, Tianyou;Zhang, Qing;Li, Zhen;Li, Yihan;Xu, Yi;Yao, Wei;Zhang, Muqing;Chen, Baoshan;Qi, Yiying;Wang, Yongjun;Wang, Yuhao;Li, Shuangyu;Qi, Nameng;Feng, Xiaoxi;Wu, Mingxing;Du, Cuicui;Deng, Zuhu;Qi, Yongwen;Huang, Yumin;Zhang, Yixing;Mei, Jing;Pan, Haoran;Liu, Jia;Chen, Shuqi;Fang, Yaxue;Ma, Panpan;Sun, Yuanchang;Ming, Ray;Tang, Haibao;Wang, Gang;Li, Qingyun;Feng, Xiaomin;Liu, Xinlong;Wang, Jianping
关键词:
-
Porcine Epidemic Diarrhea Virus Is Inhibited by GS-441524 During an In Vitro Infection
作者:Dong, Shijuan;Chen, Bingqing;Si, Fusheng;Li, Chunhua;Yu, Ruisong;Liu, Huili;Sun, Rujing;Zhang, Daojing
关键词:porcine epidemic diarrhea virus (PEDV); GS-441524; antiviral; virus replication
-
Isolation and characterization of a novel Paenibacillus species from high-salt environment with broad-spectrum antimicrobial activity against food spoilage microorganisms
作者:Han, Fei;Tong, Danni;Guo, Zixuan;Li, Zhen;Du, Rubing;Xu, Qing;Zhang, Zhidong
关键词:Food safety; Paenibacillus sp. C42; Secondary metabolites; Extreme environments; Antimicrobial activity
-
rFIP-nha activates macrophages towards a pro-inflammatory phenotype via AIM2 inflammasome modulation
作者:Liu, Yusi;Wichers, Harry;Bastiaan-Net, Shanna;Hoppenbrouwers, Tamara;Liu, Yusi;Wichers, Harry;Liu, Yusi;Li, Zhen;Hoppenbrouwers, Tamara
关键词:immunomodulatory protein; macrophage; pro-inflammatory; IL-1 beta; AIM2 inflammasome; glycosylation
-
Impact of Lonicera hypoglauca leaf inclusion on immune and antioxidant responses in geese
作者:Lv, Zonghao;Li, Zhen;Chen, Qinghua;Lv, Zonghao;Zhang, Zhizhong;Li, Gao;Lin, Qian
关键词:Lonicera hypoglauca leaves; substation; geese; antioxidant capacity, immune function
-
Enhancing pest control in pear orchards: Harnessing nanocarrier SPc for efficient delivery of emamectin benzoate and dslgl to safeguard beneficial insects
作者:Li, Jianying;Zhang, Dongyue;Wang, Yilin;Li, Zhen;Liu, Xiaoxia;Zhang, Songdou;Li, Jianying;Zhang, Dongyue;Wang, Yilin;Li, Zhen;Liu, Xiaoxia;Zhang, Songdou;Xing, Kun;Zhao, Fei;Zhang, Songdou
关键词:Insecticide; Lethal giant larvae (lgl) gene; Grapholitha molesta; Cacopsylla chinensis; biopesticide