Determination of the full-genome sequence of hepatitis E virus (HEV) SAAS-FX17 and use as a reference to identify putative HEV genotype 4 virulence determinants

文献类型： 外文期刊

第一作者： Zhu, Yumin

作者： Zhu, Yumin;Yu, Ruisong;Dong, Shijuan;Si, Fusheng;Li, Zhen;Zhu, Yumin;Yu, Ruisong;Dong, Shijuan;Si, Fusheng;Li, Zhen;Yu, Xiaoming;Zhang, Yuanshu;Huang, Fenfen

作者机构：

关键词： Hepatitis E virus;Disease severity determinant;Subtype;Genotype;Zoonosis

期刊名称：VIROLOGY JOURNAL （ 影响因子：4.099； 五年影响因子：3.719 ）

ISSN： 1743-422X

年卷期： 2012 年 9 卷

页码：

收录情况： SCI

摘要： Background: Four major genotypes of hepatitis E virus (HEV), the causative agent of hepatitis E, have so far been recognized. While genotypes 3 and 4 are both zoonotic, the disease symptoms caused by the latter tend to be more severe. To examine if specific nucleotide/amino acid variations between genotypes 3 and 4 play a role in determining the severity of hepatitis E disease, the complete genome of one swine HEV genotype 4 isolate, SAAS-FX17, was determined and compared with other genotype 4 and genotype 3 genomes to identify putative HEV genotype 4 virulence determinants. Results: A total of 42 conformable nt/aa variations between genotype 3 and 4 HEVs were detected, of which 19 were proposed to be potential disease severity determinants for genotype 4 strains. Conclusions: One potential determinant was located in each of the 5'-UTR and 3'-UTR, 3 and 12 within ORF1 and ORF2 respectively, and 2 in the junction region.

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