Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells
文献类型: 外文期刊
第一作者: Wu, Y.
作者: Wu, Y.;Gao, F.;Yang, P.;Fang, Y.;Tang, Q.;Li, W.
作者机构:
关键词: Oridonin;apoptosis;ROS;leukemia;differentiation
期刊名称:INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY ( 影响因子:2.877; 五年影响因子:2.921 )
ISSN: 1751-5521
年卷期: 2010 年 32 卷 1 期
页码:
收录情况: SCI
摘要: We investigated the effects of oridonin (Ori), a diterpenoid isolated from Rabdosia rubescens, on apoptosis and differentiation of all-trans-retinoic acid (ATRA)-sensitive (NB4) and ATRA-resistant (NB4-R1) cells. The results showed that reactive oxygen species initiates Ori-induced apoptosis. In addition, we found that neither Ori nor ATRA (10 nm) alone induced marked cell differentiation, while co-treatment of these two compounds can induce differentiation of NB4 and NB4-R1 cells which was accompanied by increased RAR alpha, C/EBP epsilon or C/EBP beta. This is the first report to show that RAR alpha could be accumulated by Ori which may be useful as a probe to investigate the mechanism of RAR alpha catabolism. These results suggest that Ori is a potential candidate for acute promyelocytic leukemia cancer therapy.
分类号:
- 相关文献
作者其他论文 更多>>
-
Optimizing the Ultrasound-Assisted Extraction of Total Cardiac Glycosides from the Milk of Calotropis Gigantea with Response Surface Methodology
作者:Gao, Z. Y.;Gong, R.;Zha, F.;Gong, R.;Gao, F.
关键词:ultrasound-assisted extraction; cardiac glycoside; Calotropis gigantea; response surface method; Box-Behnken design
-
Circulating Metabolites and Dental Traits: A Mendelian Randomization Study
作者:Zheng, Q.;Zeng, C.;Zheng, Q.;Zeng, C.;Li, W.;Liu, X.;Luo, S.;Deng, X.;Li, W.;Liu, X.;Deng, X.;Li, W.;Zhang, Y.;Zeng, C.;Liu, X.;Fu, Y.;Zeng, C.
关键词:mendelian randomization analysis; metabolomics; genome wide association study; causality; oral health; metabolic pathways
-
Low-depth Raw Reads of Nanopore Sequencing Enables Rapid and Accurate Bacterial Identification
作者:Gao, W.;Hong, W.;Wu, Y.;Liu, Y.;Fan, X.;Wang, H.;Wang, M.;Yang, B.;Wang, T.;Li, H.;Liu, S.;Li, J.
关键词:assembly; reads; Nanopore sequencing; Illumina sequencing; bacterial identification
-
PRODUCTION OF MICROBIOLOGICAL PROTEIN FEED FROM SWEET POTATO (Ipomoea batatas L. Lam) RESIDUE BY CO-CULTIVATION SACCHAROMYCES CEREVISIAE AND CANDIDA UTILIS
作者:Jin, Y. L.;Shen, W. L.;Fang, Y.;Yi, Z. L.;Yang, L.;Zhao, H.;Ding, F.;Jin, Y. L.
关键词:Sweet potato starch residue; Protein Feed; Saccharomyces cerevisiae; Candida utilis; Resource regeneration
-
Intrinsic morphology and spatial distribution of non-structural carbohydrates contribute to drought resistance of two mulberry cultivars
作者:Zhai, Z.;Fang, Y.;Cheng, J.;Tian, Y.;Liu, L.;Cao, X.;Zhai, Z.;Fang, Y.;Cheng, J.;Tian, Y.;Liu, L.;Cao, X.;Liu, L.;Cao, X.
关键词:drought stress; gas exchange; Morus; root-shoot ratio; soluble sugars; starch
-
Fusarioid Fungi Associated with Woody Plants in Russia
作者:Litovka, Y. A.;Pavlov, I. N.;Litovka, Y. A.;Pavlov, I. N.;Chen, H.;Li, W.
关键词:plant pathogenic fungi; species complexes; identification; host plant; woody plants; fusarioid fungi; Fusarium; Neocosmospora
-
Creatine nitrate supplementation strengthens energy status and delays glycolysis of broiler muscle via inhibition of LKB1/AMPK pathway
作者:Duan, B. B.;Xu, J. W.;Xing, T.;Zhang, L.;Gao, F.;Li, J. L.
关键词:broiler; creatine nitrate; meat quality; energy status; glycolysis