Apoptosis inducing and differentiation enhancement effect of oridonin on the all-trans-retinoic acid-sensitive and -resistant acute promyelocytic leukemia cells

文献类型: 外文期刊

第一作者: Wu, Y.

作者: Wu, Y.;Gao, F.;Yang, P.;Fang, Y.;Tang, Q.;Li, W.

作者机构:

关键词: Oridonin;apoptosis;ROS;leukemia;differentiation

期刊名称:INTERNATIONAL JOURNAL OF LABORATORY HEMATOLOGY ( 影响因子:2.877; 五年影响因子:2.921 )

ISSN: 1751-5521

年卷期: 2010 年 32 卷 1 期

页码:

收录情况: SCI

摘要: We investigated the effects of oridonin (Ori), a diterpenoid isolated from Rabdosia rubescens, on apoptosis and differentiation of all-trans-retinoic acid (ATRA)-sensitive (NB4) and ATRA-resistant (NB4-R1) cells. The results showed that reactive oxygen species initiates Ori-induced apoptosis. In addition, we found that neither Ori nor ATRA (10 nm) alone induced marked cell differentiation, while co-treatment of these two compounds can induce differentiation of NB4 and NB4-R1 cells which was accompanied by increased RAR alpha, C/EBP epsilon or C/EBP beta. This is the first report to show that RAR alpha could be accumulated by Ori which may be useful as a probe to investigate the mechanism of RAR alpha catabolism. These results suggest that Ori is a potential candidate for acute promyelocytic leukemia cancer therapy.

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