TIP60 contributes to porcine embryonic development by regulating DNA damage response

文献类型： 外文期刊

第一作者： Guo, Jing

作者： Guo, Jing;Zhou, Wenjun;Niu, Ying-Jie;Shin, Kyung-Tae;Kim, Nam-Hyung;Cui, Xiang-Shun;Guo, Jing;Heo, Young Tae

作者机构：

关键词： TIP60;ROS;DNA damage;Embryonic development

期刊名称：THERIOGENOLOGY （ 影响因子：2.74； 五年影响因子：2.93 ）

ISSN： 0093-691X

年卷期： 2018 年 108 卷

页码：

收录情况： SCI

摘要： The acetyltransferase TIP60 (also known as Kat5) is a member of the MYST family of histone acetyl-transferases and was initially identified as a cellular protein. TIP60 acetylates histone and non-histone proteins and is involved in diverse biological processes, including apoptosis, cell cycle, and DNA damage responses. In this study, a specific inhibitor of TIP60 was used to detect the function of TIP60 in porcine parthenogenetic embryos. The results showed that TIP60 inhibition impaired porcine parthenogenetic embryonic development. The mechanism of TIP60 was also determined. We found that the TIP60 inhibition impaired embryonic development by ROS induced DNA damage, as demonstrated by the number of gamma H2A in the nuclei. TIP60 inhibition triggered DNA damage through the regulation of p53-p21 pathway and TIP60 played a role in DNA repair. TIP60 inhibition decreased the efficiency of DNA repair by regulating 53BP1-dependent repair after DNA damage. Inhibition of TIP60 also increased the adaptive response, autophagy, by modulating LC3. Therefore, TIP60 plays a role in early porcine parthenogenetic embryonic development by regulating DNA damage and repair. (C) 2017 Elsevier Inc. All rights reserved.

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