Aflatoxin B1 impairs the growth and development of chicken PGCs through oxidative stress and mitochondrial dysfunction

文献类型： 外文期刊

第一作者： Niu, Ying-Jie

作者： Niu, Ying-Jie;Wu, Jun;Ren, Wenjie;Liu, Guangzheng;Wu, Gaoyuan;Peng, Yixiu;Zheng, Dan;Jin, Kai;Zuo, Qisheng;Chen, Guohong;Li, Bichun;Wu, Jun;Ren, Wenjie;Liu, Guangzheng;Wu, Gaoyuan;Peng, Yixiu;Zheng, Dan;Zuo, Qisheng;Chen, Guohong;Li, Bichun;Li, Guohui;Han, Wei;Cui, Xiang-Shun

作者机构：

关键词： Aflatoxin B1; Primordial germ cells; Oxidative stress; Mitochondrion; NRF2

期刊名称：ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY （ 影响因子：6.1； 五年影响因子：6.4 ）

ISSN： 0147-6513

年卷期： 2025 年 290 卷

页码：

收录情况： SCI

摘要： Aflatoxins harm the reproductive system and gamete development in animals. Primordial germ cells (PGCs) in chickens, as ancestral cells of gametes, are essential for genetic transmission, yet the impact and mechanisms of aflatoxins on them remain elusive. This study systematically investigated the effects of aflatoxin B1 (AFB1) on chicken PGCs and their potential mechanisms using an in vitro culture model. We observed a significant reduction in PGC numbers and an increase in apoptosis levels with AFB1 treatment. Further analysis revealed that AFB1 induced mitochondrial structural and functional abnormalities. Additionally, AFB1 treatment led to increased oxidative stress, lipid peroxidation, ferroptosis, and autophagy in chicken PGCs, ultimately affecting their biological characteristics. Interestingly, we found that the NRF2-mediated antioxidant pathway was activated in AFB1-treated PGCs. Inhibiting NRF2 exacerbated oxidative stress and cell death in PGCs, suggesting NRF2 upregulation plays a protective role under AFB1 regulation. This study illuminates AFB1's toxic effects on chicken PGCs and provides insights into potential mechanisms, establishing a basis for strategies to prevent and treat AFB1's adverse effects on poultry genetic transmission.

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