The Mycotoxin Zearalenone Hinders Candida albicans Biofilm Formation and Hyphal Morphogenesis

文献类型: 外文期刊

第一作者: Rajasekharan, Satish Kumar

作者: Rajasekharan, Satish Kumar;Lee, Jin-Hyung;Lee, Jintae;Zhao, Yueju

作者机构:

关键词: C. albicans;Zearalenone;Biofilms;Hyphal growth;Mycotoxins

期刊名称:INDIAN JOURNAL OF MICROBIOLOGY ( 影响因子:2.461; 五年影响因子:2.259 )

ISSN: 0046-8991

年卷期: 2018 年 58 卷 1 期

页码:

收录情况: SCI

摘要: Yeast-mold mycobiota inhabit several natural ecosystems, in which symbiotic relationships drive strategic pathoadaptation. Mycotoxins are metabolites produced by diverse mycotoxigenic fungi as a defense against yeasts, though at times yeasts secrete enzymes that degrade, detoxify, or bio-transform mycotoxins. The present study is focused on the in vitro inhibitory effects of zearalenone (ZEN), a F2 mycotoxin produced by several Fusarium and Gibberella species, on different microbial strains. ZEN exhibited no effect on the planktonic growth or biofilms of several Gram positive and negative bacteria at the tested concentrations. Remarkably, Candida albicans biofilm formation and hyphal morphogenesis were significantly inhibited when treated with 100 A mu g/mL of ZEN. Likewise, ZEN proficiently disrupted pre-formed C. albicans biofilms without disturbing planktonic cells. Furthermore, these inhibitions were confirmed by crystal violet staining and XTT reduction assays and by confocal and scanning electron microscopy. In an in vivo model, ZEN significantly suppressed C. albicans infection in the nematode Caenorhabditis elegans. The study reports the in vitro antibiofilm efficacy of ZEN against C. albicans strains, and suggests mycotoxigenic fungi participate in asymmetric competitive interactions, such as, amensalism or antibiosis, rather than commensal interactions with C. albicans, whereby mycotoxins secreted by fungi destroy C. albicans biofilms.

分类号:

  • 相关文献

[1]Mycotoxin detection - Recent trends at global level. Selvaraj, Jonathan Nimal,Zhou Lu,Wang Yan,Zhao Yue-ju,Xing Fu-guo,Dai Xiao-feng,Liu Yang. 2015

[2]Characterization of Streptococcus suis isolates from the diseased pigs in China between 2003 and 2007. Wei, Zigong,Li, Ran,Zhang, Anding,He, Hongkui,Hua, Yafeng,Xia, Jing,Chen, Huanchun,Jin, Meilin,Wei, Zigong,Li, Ran,Zhang, Anding,He, Hongkui,Hua, Yafeng,Xia, Jing,Chen, Huanchun,Jin, Meilin,Cai, Xuehui.

[3]Fusarium Populations on Chinese Barley Show a Dramatic Gradient in Mycotoxin Profiles. van der Lee, T.,Waalwijk, C.,Yang, L.,Yang, X.,Yu, D..

[4]Gene Expression Profiling Related to Hyphal Growth in a Temperature-Sensitive Mutant of Magnaporthe oryzae. Li Xue-song,Wang Hong-kai,Lin Fu-cheng,Xu Fei. 2013

[5]The tubulin cofactor A is involved in hyphal growth, conidiation and cold sensitivity in Fusarium asiaticum. Zhang, Xiaoping,Chen, Xiang,Yu, Menghao,Yin, Yanni,Ma, Zhonghua,Jiang, Jinhua. 2015

[6]Cloning, expression of a peroxiredoxin gene from Acinetobacter sp SM04 and characterization of its recombinant protein for zearalenone detoxification. Yu, Yuanshan,Wu, Hui,Yu, Yuanshan,Wu, Hui,Tang, Yuqian,Qiu, Liping. 2012

[7]Biological detoxification of zearalenone by Aspergillus niger strain FS10. Sun, Xiulan,He, Xingxing,Li, Yun,Qian, He,Li, Yun,Xu, Dan,Xue, Kathy Siyu. 2014

[8]Rapid detection and quantification of zearalenone-producing Fusarium species by targeting the zearalenone synthase gene PKS4. Meng, Kun,Wang, Yaru,Yang, Peilong,Luo, Huiying,Bai, Yingguo,Shi, Pengjun,Yuan, Tiezheng,Ma, Rui,Yao, Bin. 2010

[9]Secretory expression and characterization of a novel peroxiredoxin for zearalenone detoxification in Saccharomyces cerevisiae. Wu, Hui,Yu, Yuanshan. 2013

[10]The Antagonistic Effect of Mycotoxins Deoxynivalenol and Zearalenone on Metabolic Profiling in Serum and Liver of Mice. Ji, Jian,Cui, Fangchao,Pi, Fuwei,Zhang, Yinzhi,Li, Yun,Wang, Jiasheng,Sun, Xiulan,Zhu, Pei,Ji, Jian,Zhu, Pei,Cui, Fangchao,Pi, Fuwei,Zhang, Yinzhi,Sun, Xiulan,Li, Yun,Wang, Jiasheng. 2017

[11]Screening and monitoring zearalenone-producing Fusarium species by PCR and zearalenone by monoclonal antibodies in feed from China. Pei, Shi-Chun,Zhang, Hong-Fu,Ji, Cheng,Pei, Shi-Chun,Zhen, Yu-Ping,Gao, Jian-Wei,Lee, Won-Jong,Chen, Cong,Zhang, Xuan-Zhe.

[12]Iron (II, III) oxide/multi-walled carbon nanotube composite as solid-phase extraction sorbent followed by ultra-high performance liquid chromatography tandem mass spectrometry for simultaneous determination of zearalenone and type A trichothecenes in Salviae miltiorrhizae Radix et Rhizoma (Danshen). Jiang, Keqiu,Huang, Peng,Luan, Lianjun,Wu, Yongjiang,Fan, Kai,Guo, Wenbo,Zhao, Zhihui,Han, Zheng.

[13]Recent mycotoxin survey data and advanced mycotoxin detection techniques reported from China: a review. Selvaraj, Jonathan Nimal,Wang, Yan,Zhou, Lu,Zhao, Yueju,Xing, Fuguo,Dai, Xiaofeng,Liu, Yang.

[14]A novel detoxifying agent: Using rice husk carriers to immobilize zearalenone-degrading enzyme from Aspergillus niger FS10. He, Mengling,Li, Yun,Pi, Fuwei,Ji, Jian,He, Xingxing,Zhang, Yinzhi,Sun, Xiulan,Li, Yun.

[15]Individual and combined cytotoxicity assessment of zearalenone with ochratoxin A or alpha-zearalenol by full factorial design. Zheng, N.,Gao, Y. N.,Wang, H. W.,Wang, J. Q.,Zheng, N.,Gao, Y. N.,Wang, J. Q.,Wang, H. W.,Liu, J.. 2018

[16]Rapid and sensitive quantitation of zearalenone in food and feed by lateral flow immunoassay. Liu, Gang,Han, Zheng,Nie, Dongxia,Yang, Junhua,Zhao, Zhihui,Song, Suquan,Wu, Aibo,Liu, Gang,Zhang, Jingbo,Li, Heping,Liao, Yucai,Song, Suquan,De Saeger, Sarah. 2012

[17]Metabolic Profile of Zearalenone in Liver Microsomes from Different Species and Its in Vivo Metabolism in Rats and Chickens Using Ultra High-Pressure Liquid Chromatography-Quadrupole/Time-of-Flight Mass Spectrometry. Yang, Shupeng,Zhang, Jinzhen,Jin, Yue,Zhou, Jinhui,Li, Yi,Yang, Shupeng,Zhang, Huiyan,De Ruyck, Karl,De Saeger, Sarah,De Boevre, Marthe,Yang, Shupeng,Zhang, Huiyan,Sun, Feifei,Wang, Zhanhui,Zhang, Suxia,Li, Yanshen. 2017

[18]Effects of aflatoxin B1 combined with ochratoxin A and/or zearalenone on metabolism, immune function, and antioxidant status in lactating dairy goats. Huang, Shuai,Fan, Caiyun,Wang, Shang,Cheng, Jianbo,Zheng, Nan,Jabar, Adil,Wang, Jiaqi,Cheng, Ming. 2018

[19]Multi-component immunochromatographic assay for simultaneous detection of aflatoxin B-1, ochratoxin A and zearalenone in agro-food. Li, Xin,Li, Peiwu,Zhang, Qi,Li, Ran,Zhang, Wen,Zhang, Zhaowei,Ding, Xiaoxia,Tang, Xiaoqian,Li, Xin,Zhang, Qi,Li, Ran,Zhang, Zhaowei,Li, Xin,Li, Peiwu,Li, Peiwu,Zhang, Zhaowei,Ding, Xiaoxia,Li, Peiwu,Zhang, Qi,Li, Ran,Zhang, Wen,Tang, Xiaoqian. 2013

[20]Evaluation of reduced toxicity of zearalenone as measured by the Hep G2 cell assay on degradation enzymes. He, Xingxing,Li, Yun,Gu, Wenshu,Sun, Yange,Sun, Xiulan,Li, Shuai,Li, Yun.

作者其他论文 更多>>