Regulation of MicroRNAs, and the Correlations of MicroRNAs and Their Targeted Genes by Zinc Oxide Nanoparticles in Ovarian Granulosa Cells

文献类型： 外文期刊

第一作者： Zhao, Yong

作者： Zhao, Yong;Liu, Xin-Qi;Zhang, Wei-Dong;Hao, Zhi-Hui;Zhao, Yong;Li, Lan;Min, Ling-Jiang;Sun, Qing-Yuan;Zhang, Wei-Dong;Ge, Wei;Wang, Jun-Jie;Liu, Jing-Cai;Zhu, Lian-Qin;Sun, Qing-Yuan;Zhang, Hong-Fu

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2016 年 11 卷 5 期

页码：

收录情况： SCI

摘要： Zinc oxide (ZnO) nanoparticles (NPs) have been applied in numerous industrial products and personal care products like sunscreens and cosmetics. The released ZnO NPs from consumer and household products into the environment might pose potential health issues for animals and humans. In this study the expression of microRNAs and the correlations of microRNAs and their targeted genes in ZnO NPs treated chicken ovarian granulosa cells were investigated. ZnSO4 was used as the sole Zn2+ provider to differentiate the effects of NPs from Zn2+. It was found that ZnO-NP-5 mu g/ml specifically regulated the expression of microRNAs involved in embryonic development although ZnO-NP-5 mu g/ml and ZnSO4-10 mu g/ml treatments produced the same intracellular Zn concentrations and resulted in similar cell growth inhibition. And ZnO-NP-5 mu g/ml also specifically regulated the correlations of microRNAs and their targeted genes. This is the first investigation that intact NPs in ZnO-NP-5 mu g/ml treatment specifically regulated the expression of microRNAs, and the correlations of microRNAs and their targeted genes compared to that by Zn2+. This expands our knowledge for biological effects of ZnO NPs and at the same time it raises the health concerns that ZnO NPs might adversely affect our biological systems, even the reproductive systems through regulation of specific signaling pathways.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序