TMK4-mediated FIP37 phosphorylation regulates auxin-triggered N6-methyladenosine 6-methyladenosine modification of auxin biosynthetic genes in Arabidopsis

文献类型： 外文期刊

第一作者： Li, Bin

作者： Li, Bin;Zhou, Qiting;Cai, Linjun;Xie, Chong;Li, Donghao;Zhu, Fan;Li, Xiushan;Zhao, Xiaoying;Liu, Xuanming;He, Chongsheng;Li, Bin;Shen, Lisha;Xu, Tongda;Li, Lan

作者机构：

期刊名称：CELL REPORTS （ 影响因子：7.5； 五年影响因子：8.5 ）

ISSN： 2211-1247

年卷期： 2024 年 43 卷 8 期

页码：

收录情况： SCI

摘要： The dynamics of N 6-methyladenosine (m6A) 6 A) mRNA modification are tightly controlled by the m6A 6 A methyltransferase complex and demethylases. Here, we find that auxin treatment alters m6A 6 A modification on auxin-responsive genes. Mechanically, TRANSMEMBRANE KINASE 4 (TMK4), a component of the auxin signaling pathway, interacts with and phosphorylates FKBP12-INTERACTING PROTEIN 37 (FIP37), a core component of the m6A 6 A methyltransferase complex, in an auxin-dependent manner. Phosphorylation of FIP37 enhances its interaction with RNA, thereby increasing m6A 6 A modification on its target genes, such as NITRILASE 1 (NIT1), NIT1 ), a gene involved in indole-3-acetic acid (IAA) biosynthesis. 1-Naphthalacetic acid (NAA) treatment accelerates the mRNA decay of NIT1, , in a TMK4- and FIP37-dependent manner, which leads to inhibition of auxin biosynthesis. Our findings identify a regulatory mechanism by which auxin modulates m6A 6 A modification through the phosphorylation of FIP37, ultimately affecting mRNA stability and auxin biosynthesis in plants.

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