Leojaponic acids A and B, two new homologous terpenoids, isolated from Leonurus japonicus

文献类型： 外文期刊

第一作者： WU Han-Kui

作者： WU Han-Kui;MAO Yan-Jun;SUN Shan-Shan;XU Zhi-Yong;MA Ya;CAO Jin-Xia;QI He;WU Zhi-Fu;LI Gang;YANG Wei-Hua

作者机构：

关键词： Leonurus japonicus;Leojaponic acid;Terpenoid

期刊名称：CHINESE JOURNAL OF NATURAL MEDICINES （ 影响因子：3.0； 五年影响因子：2.869 ）

ISSN： 2095-6975

年卷期： 2016 年 14 卷 4 期

页码：

收录情况： SCI

摘要： The present study aimed at isolation and purification of the bioactive terpenoids from the herb of Leonurus japonicus by chromatographic separations such as silica gel, sephadex LH-20 and C-18 reversed phase silica gel, as well as preparative HPLC. As a result, leojaponic acids A (1, C17H24O4) and B (2, C18H26O4), two homologous terpenoids, together with (-)-loliolide (3), 1-(3-ethylphenyl) ethane-1, 2-diol (4) and dibutyl phthalate (5), were isolated from the EtOH extract of L. japonicus. All the chemical structures of the isolates were elucidated on the basis of 1D and 2D NMR analyses. Compounds 1 and 2 were new terpenoids, and Compounds 3 and 4 were isolated and identified for the first time from this plant. In addition, the alpha-glucosidase and tyrosinase inhibitory activity of the new compounds were evaluated.

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