A Rare SNP Identified a TCP Transcription Factor Essential for Tendril Development in Cucumber

文献类型： 外文期刊

第一作者： Wang, Shenhao

作者： Wang, Shenhao;Yang, Xueyong;Xu, Mengnan;Lin, Tao;Qi, Jianjian;Shao, Guangjin;Zhang, Zhonghua;Huang, Sanwen;Wang, Shenhao;Xu, Mengnan;Huang, Sanwen;Lin, Xingzhong;Tian, Nana;Yang, Qing;Qi, Jianjian

作者机构：

关键词： rare variant;TCP transcription factor;cucumber tendril;homologous organs

期刊名称：MOLECULAR PLANT （ 影响因子：13.164； 五年影响因子：16.357 ）

ISSN： 1674-2052

年卷期： 2015 年 8 卷 12 期

页码：

收录情况： SCI

摘要： Rare genetic variants are abundant in genomes but less tractable in genome-wide association study. Here we exploit a strategy of rare variation mapping to discover a gene essential for tendril development in cucumber ( Cucumis sativus L.). In a collection of > 3000 lines, we discovered a unique tendril-less line that forms branches instead of tendrils and, therefore, loses its climbing ability. We hypothesized that this unusual phenotype was caused by a rare variation and subsequently identified the causative single nucleotide polymorphism. The affected gene TEN encodes a TCP transcription factor conserved within the cucurbits and is expressed specifically in tendrils, representing a new organ identity gene. The variation occurs within a protein motif unique to the cucurbits and impairs its function as a transcriptional activator. Analyses of transcriptomes from near-isogenic lines identified downstream genes required for the tendril's capability to sense and climb a support. This study provides an example to explore rare functional variants in plant genomes.

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[1]Genome-wide analysis of TCP family in tobacco. Chen, L.,Ding, A. M.,Chen, H.,Xia, F.,Wang, W. F.,Sun, Y. H.,Chen, L.,Chen, H.,Xia, F.,Wang, W. F.,Chen, Y. Q.. 2016

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