Determination of the infectious titer and virulence of an original US porcine epidemic diarrhea virus PC22A strain
文献类型： 外文期刊
第一作者： Liu, Xinsheng
作者： Liu, Xinsheng;Lin, Chun-Ming;Annamalai, Thavamathi;Gao, Xiang;Lu, Zhongyan;Esseili, Malak A.;Jung, Kwonil;El-Tholoth, Mohamed;Saif, Linda J.;Wang, Qiuhong;Liu, Xinsheng;El-Tholoth, Mohamed
作者机构：
期刊名称：VETERINARY RESEARCH （ 影响因子：3.683； 五年影响因子：4.106 ）
ISSN： 0928-4249
年卷期： 2015 年 46 卷
页码：
收录情况： SCI
摘要： The infectious dose of a virus pool of original US PEDV strain PC22A was determined in 4-day-old, cesarean-derived, colostrum-deprived (CDCD) piglets. The median pig diarrhea dose (PDD50) of the virus pool was determined as 7.35 log(10) PDD50/mL, similar to the cell culture infectious titer, 7.75 log(10) plaque-forming units (PFU)/mL. 100 PDD50 caused watery diarrhea in all conventional suckling piglets (n = 12) derived from a PEDV- naive sow, whereas 1000 and 10 000 PDD50 did not cause diarrhea in piglets derived from two PEDV-field exposed-recovered sows. This information is important for future PEDV challenge studies and validation of PEDV vaccines.
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