Dietary curcumin supplementation attenuates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in C57BL mice

文献类型： 外文期刊

第一作者： He, Xi-Jun

作者： He, Xi-Jun;He, Xi-Jun;Uchida, Kazuyuki;Nakayama, Hiroyuki;Megumi, Chiaki;Tsuge, Nobuaki

作者机构：

关键词： MPTP;curcumin;neuroprotective;dopamine;astrocyte;microglia

期刊名称：JOURNAL OF TOXICOLOGIC PATHOLOGY （ 影响因子：1.628； 五年影响因子：1.689 ）

ISSN： 0914-9198

年卷期： 2015 年 28 卷 4 期

页码：

收录情况： SCI

摘要： Studies in vivo and in vitro suggest that curcumin is a neuroprotective agent. Experiments were conducted to determine whether dietary supplementation with curcumin has neuroprotective effects in a mouse model of Parkinson's disease (PD). Treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) significantly induced the loss of dopaminergic cells in the substantia nigra and deletion of dopamine in the striatum, which was attenuated by long-term (7 weeks) dietary supplementation with curcumin at a concentration of 0.5% or 2.0% (w/w). Although curcumin did not prevent the MPTP-induced apoptosis of neuroblasts in the subventricular zone (SVZ), it promoted the regeneration of neuroblasts in the anterior part of the SVZ (SVZa) at 3 days after MPTP treatment. Furthermore, curcumin enhanced the MPTP-induced activation of microglia and astrocytes in the striatum and increased the expression of glial cell line-derived neurotrophic factor (GDNF) and transforming growth factor-beta 1 (TGF beta 1) in the striatum and SVZ. GDNF and TGF beta 1 are thought to play an important role in protecting neurons from injury in the central and peripheral nervous systems. These results suggest that long-term administration of curcumin blocks the neurotoxicity of MPTP in the nigrostriatal dopaminergic system of the mouse and that the neuroprotective effect might be correlated with the increased expression of GDNF and TGF beta 1. Curcumin may be effective in preventing or slowing the progression of PD.

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