The Expression of Can and Camk is Associated with Lipogenesis in the Muscle of Chicken

文献类型： 外文期刊

第一作者： Yang, Y.

作者： Yang, Y.;Song, J.;Fu, R.;Sun, Y.;Wen, J.

作者机构：

关键词： Ca2+/calmodulin-dependent protein kinase;calcineurin;chicken;regulation

期刊名称：BRAZILIAN JOURNAL OF POULTRY SCIENCE （ 影响因子：0.826； 五年影响因子：1.178 ）

ISSN： 1516-635X

年卷期： 2015 年 17 卷 3 期

页码：

收录情况： SCI

摘要： Intramuscular fat (IMF) content in chickens significantly contributes to meat quality. The main objective of this study was to assess the expression of calcineurin (CaN) and Ca2+/calmodulin-dependent protein kinase (CaMK) in lipogenesis in chicken muscle. Chickens were slaughtered and sampled at 4, 8, and 16 weeks of age. IMF content and the expression of CaN subunits and CaMK isoforms were measured in the thigh muscle tissue. The results showed that the IMF contents were greater at 16 weeks compared with those at 4 and 8 weeks (p<0.05). Transcription of fatty acid synthase (FAS) and fatty acid translocase CD36 (FAT/CD36) mRNA significantly increased with age, from four to 16 weeks (p<0.05). The mRNA levels of CaN B and CaMK IV were significantly lower at 16 weeks than at four weeks (p<0.05), but CaMK II mRNA levels were significantly higher than at four weeks (p<0.05). In order to evaluate the role of CaMK and CaN in adipogenesis, SV cells were incubated in standard adipogenic medium for 24 h and treated with specific inhibitor of CaMK and CaN. The expressions of CCAAT/enhancer binding protein beta (C/EBP beta), sterol regulatory element-binding protein 1 (SREBP1), and peroxisome proliferation-activated receptor. (PPAR.) were dramatically enhanced by the CsA, CaN inhibitor (p<0.05). KN93, CaMK II inhibitor, dramatically repressed the expression of those lipogenic gene (p<0.05). These results indicated that CaN and CaMK had different effects on adipogenesis in the muscle of chickens.

分类号：

  • 相关文献

[1]Differentiation of expression profiles of two calcineurin subunit genes in chicken skeletal muscles during early postnatal growth depending on anatomical location of muscles and breed. Shan Yan-ju,Xu Wen-juan,Shu Jing-ting,Zhang Ming,Song Wei-tao,Tao Zhi-yun,Zhu Chun-hong,Li Hui-fang. 2016

[2]Effect of mouse calcineurin on induction and growth of rice callus transformed by the calcineurin gene. Ma, Xujun,Qian, Qian,Yang, Chuanping,Liu, Guifeng,Zhu, Dahai. 2006

[3]Activation of cAMP-response element-binding protein is positively regulated by PKA and calcium-sensitive calcineurin and negatively by PKC in insect. Yang, Huipeng,He, Xiaobai,Deng, Xiaoyan,Liao, Yuan,Zhu, Chenggang,Shi, Ying,Zhou, Naiming,Yang, Jingwen,Zhang, Zhifang.

[4]Expression of a calcineurin gene improves salt stress tolerance in transgenic rice. Ma, XJ,Qian, Q,Zhu, DH.

[5]Effects of immunological challenge induced by lipopolysaccharide on skeletal muscle fiber type conversion of piglets. Jia, A. F.,Feng, J. H.,Zhang, M. H.,Chang, Y.,Li, Z. Y.,Hu, C. H.,Zhen, L.,Zhang, S. S.,Peng, Q. Q..

[6]Expression pattern of adipocyte fatty acid-binding protein gene in different tissues and its regulation of genes related to adipocyte differentiation in duck. He, J.,Tian, Y.,Li, J. J.,Shen, J. D.,Tao, Z. R.,Lu, L. Z.,He, J.,Fu, Y.,Niu, D.,Lu, L. Z.. 2012

[7]Dissecting the biological relationship between TCGA miRNA and mRNA sequencing data using MMiRNA-Viewer. Bai, Yongsheng,Ding, Lizhong,Rath, Ethan,Stuart, Gary,Bai, Yongsheng,Stuart, Gary,Baker, Steve,Jiang, Feng,Bai, Jenny M.,Wu, Jianghong,Jiang, Hui. 2016

[8]De Novo Assembly and Characterization of the Transcriptome of the Chinese Medicinal Herb, Gentiana rigescens. Zhang, Xiaodong,Li, Caixia,Allan, Andrew C.,Wang, Yuanzhong,Yao, Qiuyang. 2015

[9]Regulation of gaseous signaling molecules on proline metabolism in plants. He, Huyi,He, Long-Fei. 2018

[10]Transcriptome Analyses Shed New Insights into Primary Metabolism and Regulation of Blumeria graminis f. sp tritici during Conidiation. Zeng, Fan-Song,Yang, Li-Jun,Yu, Da-Zhao,Zeng, Fan-Song,Xue, Min-Feng,Zhang, Xue-Jiang,Gong, Shuang-Jun,Yang, Li-Jun,Shi, Wen-Qi,Yu, Da-Zhao,Zeng, Fan-Song,Xue, Min-Feng,Zhang, Xue-Jiang,Gong, Shuang-Jun,Yang, Li-Jun,Shi, Wen-Qi,Yu, Da-Zhao,Menardo, Fabrizio. 2017

[11]Molecular characterization and NF-kappa B-regulated transcription of selenoprotein S from the Bama mini-pig. Zhang, Ningbo,Jing, Wenqian,Cheng, Jiayue,Cui, Wentao,Mu, Yulian,Li, Kui,Jing, Wenqian,Cheng, Jiayue,Lei, Xingen.

[12]Association Analysis of the nced and rab28 Genes with Phenotypic Traits Under Water Stress in Maize. Su, Zhijun,Li, Xinhai,Hao, Zhuanfang,Xie, Chuanxiao,Li, Mingshun,Weng, Jianfeng,Zhang, Degui,Zhang, Shihuang,Su, Zhijun,Li, Xinhai,Hao, Zhuanfang,Xie, Chuanxiao,Li, Mingshun,Weng, Jianfeng,Zhang, Degui,Zhang, Shihuang,Liang, Xiaoling,Su, Zhijun,Wang, Zhigang,Gao, Julin.

[13]LetR is a TetR family transcription factor from Lysobacter controlling antifungal antibiotic biosynthesis. Wang, Ping,Chen, Hongfu,Qian, Guoliang,Liu, Fengquan,Liu, Fengquan.

[14]Activation of miR165b represses AtHB15 expression and induces pith secondary wall development in Arabidopsis. Du, Qian,Qi, Liying,Wang, Huanzhong,Avci, Utku,Pattathil, Sivakumar,Hahn, Michael G.,Li, Shengben,Gallego-Giraldo, Lina.

[15]Mechanism of Glucose Regulates the Fruiting Body Formation in the Beech Culinary-Medicinal Mushroom, Hypsizygus marmoreus (Agaricomycetes). Zhang, Jin-Jing,Chen, Hui,Xie, Min-Ying,Chen, Ming-Jie,Hao, Hai-Bo,Wang, Hong,Feng, Zhi-Yong,Zhang, Jin-Jing,Xie, Min-Ying,Hao, Hai-Bo,Feng, Zhi-Yong.

[16]The GGDEF-domain protein GdpX1 attenuates motility, exopolysaccharide production and virulence in Xanthomonas oryzae pv. oryzae. Qian, S.,Tian, F.,Chen, H.,He, C.,Hutchins, W.,Yang, C. -H..

[17]The small auxin-up RNA OsSAUR45 affects auxin synthesis and transport in rice. Xu, Yan-Xia,Xu, Yan-Xia,Xiao, Meng-Zhu,Liu, Yan,Fu, Jun-Liang,He, Yi,Jiang, De-An.

[18]MicroRNAs Involved in Skeletal Muscle Differentiation. Zhang, Xiquan. 2013

[19]Molecular characterization of banana NAC transcription factors and their interactions with ethylene signalling component EIL during fruit ripening. Kuang, Jian-fei,Chen, Lei,Xie, Hui,Peng, Huan-huan,Xiao, Yun-yi,Li, Xue-ping,Chen, Wei-xin,Chen, Jian-ye,Lu, Wang-jin,He, Quan-guang. 2012

[20]cDNA cloning, expression and regulation analysis of goose adipose triglyceride lipase (ATGL) gene. Lu, Lizhi,Wang, Fang,Fu, Yan,Lu, Lizhi,Wang, Fang,Chen, Xiaoyan,Yuan, Hao,Tian, Yong,Li, Jinjun,Shen, Junda,Tao, Zhengrong. 2011

作者其他论文 更多>>

微信小程序