NLRP3 Inflammasome Activation by Viroporins of Animal Viruses

文献类型： 外文期刊

第一作者： Guo, Hui-Chen

作者： Guo, Hui-Chen;Jin, Ye;Zhi, Xiao-Yin;Yan, Dan;Sun, Shi-Qi

作者机构：

关键词： viroporin;inflammasome;NLRP3;animal virus

期刊名称：VIRUSES-BASEL （ 影响因子：5.048； 五年影响因子：5.127 ）

ISSN： 1999-4915

年卷期： 2015 年 7 卷 7 期

页码：

收录情况： SCI

摘要： Viroporins are a group of low-molecular-weight proteins containing about 50-120 amino acid residues, which are encoded by animal viruses. Viroporins are involved in several stages of the viral life cycle, including viral gene replication and assembly, as well as viral particle entry and release. Viroporins also play an important role in the regulation of antiviral innate immune responses, especially in inflammasome formation and activation, to ensure the completion of the viral life cycle. By reviewing the research progress made in recent years on the regulation of the NLRP3 inflammasome by viroporins of animal viruses, we aim to understand the importance of viroporins in viral infection and to provide a reference for further research and development of novel antiviral drugs.

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