Analgesic and anti-inflammatory effects of hydroalcoholic extract isolated from Semen vaccariae

文献类型： 外文期刊

第一作者： Wang, Lei

作者： Wang, Lei;Cui, Dongan;Wang, Xurong;Zhang, Jingyan;Yang, Zhiqiang;Qin, Zhe;Kong, Xiaojun;Wang, Xuezhi;Li, Jianxi

作者机构：

关键词： Semen vaccariae;Hydroalcoholic extract;analgesic activity;anti-inflammatory activity

期刊名称：PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES （ 影响因子：0.684； 五年影响因子：0.804 ）

ISSN： 1011-601X

年卷期： 2015 年 28 卷 3 期

页码：

收录情况： SCI

摘要： Semen vaccariae, the seeds of Vaccaria segetalis (Neck.) Garcke, is usually used as, an important medication for female mammary gland diseases; it has also been used to promote lactation for centuries in China. The purpose of this work was to evaluate the analgesic and anti-inflammatory effects of hydroalcoholic extract from semen vaccariae (HESV) with oral doses of 50, 100 and 200mg/kg.bw in mice and rats. We observed that the HESV could effectively inhibit acetic acid-induced. abdominal contraction and could elevate the latency time to thermal stimuli in the hot-plate test in mice. In the xylene-induced ear-swelling test in mice, HESV could suppress the ear swelling. Additionally, HESV could significantly decrease the peritoneal capillary permeability and leukocyte infiltration in mice induced by the intraperitoneal injection of acetic acid. HESV also significantly reduced paw thickness 2-4 hours after the injection of carrageenan in the carrageenan-induced rat paw edema test. This study was the first to demonstrate that the oral administration of HESV might play an important role in the process of analgesia and anti-inflammation, supporting its use for female mammary gland diseases in traditional medicine.

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